[1]易福凌,陈伟芝,王　禺.慢性心力衰竭患者血清 Mb，cTnI，IL-8 和 hs-CRP 水平表达与心功能分级的相关性研究[J].现代检验医学杂志,2021,36(03):58-61.[doi:10.3969/j.issn.1671-7414.2021.03.013]
　YI Fu-ling,CHEN Wei-zhi,WANG Yu.Correlation between the Expression of Serum MB, cTnI, IL-8, hs-CRP andCardiac Function in Patients with Chronic Heart Failure[J].Journal of Modern Laboratory Medicine,2021,36(03):58-61.[doi:10.3969/j.issn.1671-7414.2021.03.013]
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慢性心力衰竭患者血清 Mb，cTnI，IL-8 和 hs-CRP 水平表达与心功能分级的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
58-61
栏目:
论　著
出版日期:
2021-05-31

文章信息/Info

Title:
Correlation between the Expression of Serum MB, cTnI, IL-8, hs-CRP andCardiac Function in Patients with Chronic Heart Failure
文章编号:
1671-7414（2021）03-058-05
作者:
易福凌; 陈伟芝; 王　禺
(1. 西安市第一医院检验科，西安 710004；2. 西安交通大学附属红会医院检验科，西安 710054)
Author(s):
YI Fu-ling1;  CHEN Wei-zhi2;  WANG Yu1
（1.Department of Clinical Laboratory,the First Hospital of Xi’an City, Xi’an 710004, China;2.Department of ClinicalLaboratory, Red Cross Society Hospital Affiliated to Xi’an Jiaotong University, Xi’an 710054, China）
关键词:
慢性心力衰竭; 心功能分级; 肌钙蛋白 I; 肌红蛋白; 细胞白介素 -8; 超敏 C 反应蛋白
分类号:
R541.6；R446.112
DOI:
10.3969/j.issn.1671-7414.2021.03.013
文献标志码:
A
摘要:
目的　探讨慢性心力衰竭（CHF）患者血清肌红蛋白 (Mb)、心肌肌钙蛋白 I(cTnI)、白细胞介素 -8(IL-8) 及超敏 C 反应蛋白 (hs-CRP) 水平与心功能分级的相关性。方法　选择 2019 年 1~12 月期间于西安交通大学附属红会医院和西安市第一医院就诊的 150 例 CHF 患者作为观察组，另选择同期健康体检的 50 例正常人群作为对照组。采用荧光酶免法检测各组研究对象的 Mb 和 cTnI 水平。采用酶联免疫吸附法和散射免疫比浊法测定 IL-8 和 hs-CRP 水平。建立受试者工作特征 (ROC) 曲线评价 Mb，cTnI，IL-8 及 hs-CRP 在诊断 CHF 中的临床意义。比较分析血清 Mb,cTnI,IL-8 及hs-CRP 水平与心功能分级的相关性。结果　观察组和对照组的血清水平分别为 Mb(102.16±31.55μg/L vs 31.35±12.28μg/L，cTnI(3.88±1.13ng/ml vs 0.76±0.21ng/ml)，IL-8(34.71±8.46ng/ml vs 8.32±2.25ng/ml)，hs-CRP(5.62±1.73mg/L vs0.86±0.31mg/L)。观察组的血清 Mb，cTnI，IL-8 及 hs-CRP 水平均显著高于对照组（t=15.160~21.770，均 P<0.01)。Ⅰ级 ~ Ⅳ级心功能分级患者的血清水平分别为 Mb(49.17±11.35，57.45±13.74，96.22±26.16 和 155.74±39.37μg/L)，cTnI(1.39±0.47，2.73±0.68，4.01±1.32 和 5.15±1.67ng/ml)，IL-8(13.26±3.77，19.38±5.23，35.25±9.11 和54.33±11.36ng/ml)，hs-CRP(1.81±0.45，2.21±0.57，5.72±1.64 和 6.81±1.89mg/l)。不同心功能分级患者血清 Mb，cTnI，IL-8 及 hs-CRP 水平由高到低依次为：Ⅳ级 > Ⅲ级 > Ⅱ级 > Ⅰ级，差异均有统计学意义（F=66.350~134.600，均 P<0.01）。ROC 曲线分析显示血清 Mb,cTnI，IL-8 及 hs-CRP 检测 CHF 的曲线下面积（AUC) 分别为 Mb[0.78(95%CI0.623~0.851)]，cTnI[0.80(95% CI0.657~0.876)]，IL-8[0.69(95% CI0.603~0.816)]，hs-CRP[0.74(95% CI0.609~0.810)], 均P<0.01。Mb，cTnI，IL-8 及 hs-CRP 诊断 CHF 的阳性预测值、阴性预测值、敏感度及特异度分别为 Mb(75.34，63.34，80.14 和 77.39)，cTnI(74.15，61.27，75.64 和 74.88)，IL-8(68.74,59.78，72.01 和 70.47),hs-CRP(69.46，60.45，70.58 和67.46)。结论 CHF 患者血清 Mb，cTnI，IL-8 及 hs-CRP 水平均显著高于正常人群，Mb，cTnI，IL-8 及 hs-CRP 水平与患者心功能分级有正相关性。检测 Mb，TnI，IL-8 及 hs-CRP 水平可为 CHF 的早期评估提供临床依据。

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备注/Memo

备注/Memo:
基金项目：陕西省 2020 年重点研发计划 (2020SF-255)。
作者简介：易福凌 (1986-)，女，在读硕士研究生，主管检验师，研究方向：心脏疾病标志物的研究，E-mail：375542686@qq.com。
通讯作者：陈伟芝 (1984-)，女，在读硕士研究生，主管检验师，研究方向：心脏疾病标志物的研究，E-mail：2191515872@qq.com。
更新日期/Last Update: 1900-01-01