[1]杨思贤,慕奕彤,牛福玉.粪便S100A12，钙卫蛋白和乳铁蛋白对溃疡性结肠炎患者疾病活动度和黏膜愈合评估价值分析[J].现代检验医学杂志,2022,37(03):172-176.[doi:10.3969/j.issn.1671-7414.2022.03.036]
　YANG Si-xian,MU Yi-tong,NIU Fu-yu.Evaluation Value of Stool S100A12, Fecal Calprotectin and Lactoferrin for Disease Activity and Mucosal Healing in Patients with Ulcerative Colitis[J].Journal of Modern Laboratory Medicine,2022,37(03):172-176.[doi:10.3969/j.issn.1671-7414.2022.03.036]
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粪便S100A12，钙卫蛋白和乳铁蛋白对溃疡性结肠炎患者疾病活动度和黏膜愈合评估价值分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年03期
页码:
172-176
栏目:
检验与临床
出版日期:
2022-05-15

文章信息/Info

Title:
Evaluation Value of Stool S100A12, Fecal Calprotectin and Lactoferrin for Disease Activity and Mucosal Healing in Patients with Ulcerative Colitis
文章编号:
1671-7414（2022）03-172-05
作者:
杨思贤; 慕奕彤; 牛福玉
（营口市中心医院消化内科，辽宁营口 115003）
Author(s):
YANG Si-xian;  MU Yi-tong;  NIU Fu-yu
(Department of Gastroenterology, Yingkou Central Hospital, Liaoning Yingkou 115003,China)
关键词:
溃疡性结肠炎; S100A12; 钙卫蛋白; 乳铁蛋白
分类号:
R574.62；R446.13
DOI:
10.3969/j.issn.1671-7414.2022.03.036
文献标志码:
A
摘要:
目的　分析粪便 S100A12，钙卫蛋白（ fecal calprotectin ，FC）和乳铁蛋白（ lactoferrin ，LF）对溃疡性结肠炎（ulcerative colitis，UC）患者疾病活动度和黏膜愈合情况的评估价值。方法　选取 2018年 9月～ 2020年 7月期间营口市中心医院收治的 UC患者 125例，根据疾病活动度将其分为缓解组（ 72例）和活动组（ 53例），缓解组再根据黏膜情况分为黏膜愈合组（ 34例）和黏膜病变组（ 38例）。检测所有患者的粪便 S100A12，FC和 LF水平，采用 Pearson法分析粪便 S100A12，FC，LF与 UC镜下严重程度指数（ UCEIS评分）的相关性，采用受试者操作特征曲线（ROC）分析粪便 S100A12，FC和 LF对 UC患者疾病活动度和黏膜愈合的评估价值。结果　活动组的粪便 S100A12（1.21±0.36μg/g）， FC（326.38±153.54μg/g）和 LF（288.62±164.84μg/g）水平均明显高于缓解组（ 0.75±0.24μg/g, 138.52±63.28μg/g, 103.25±45.63μg/g），差异有统计学意义（ t=8.566～ 9.367，均 P<0.05）；黏膜病变组的粪便 S100A12（0.99±0.29μg/g），FC（188.94±70.94μg/g）和 LF（142.31±63.21μg/g）水平明显高于黏膜愈合组（0.48±0.21μg/ g，82.17±33.61μg/g，59.56±20.52μg/g），差异均有统计学意义（ t=7.295～ 8.458，均 P<0.05）。经 Pearson分析显示， UC患者的粪便 S100A12，FC，LF水平与 UCEIS评分均呈正相关（ r=0.426，0.438，0.417，均 P<0.05）；ROC分析显示，粪便 S100A12，FC，LF对 UC患者疾病活动度和黏膜愈合有一定的评估价值，且三者联合应用可有效提升评估价值，评估疾病活动度的曲线下面积为 0.895，敏感度和特异度分别为 88.70%和 90.28%，评估黏膜愈合的曲线下面积为 0.890，敏感度和特异度分别为 91.18%和 86.84%。结论　粪便 S100A12，FC和 LF联合应用对 UC患者疾病活动度和黏膜愈合的评估价值较高，具有一定的临床应用价值。
Abstract:
Objective　To analyze the value of stool S100A12, fecal calprotectin (FC) and lactoferrin (LF) in the evaluation of disease activity and mucosal healing in patients with ulcerative colitis (UC).Methods　125 patients with UC admitted to Yingkou Central Hospital from September 2018 to July 2020 were selected, and they were divided into remission group (72 cases) and active group (53 cases) according to disease activity. The remission group was further divided into mucosal healing group (34 cases) and mucosal lesion group (38 cases) according to the mucosal condition. The levels of stool S100A12, FC and LF in all patients were detected. Pearson method was used to analyze the correlation between stool S100A12, FC, LF and UC microscopic severity index (UCEIS score). Receiver operating characteristic curve (ROC) was used to analyze the evaluation value of stool S100A12, FC and LF for disease activity and mucosal healing of patients with UC. Results　The levels of stool S100A12（1.21±0.36μg/g），FC（326.38±153.54μg/g）and LF（288.62±164.84μg/g） in the active group were significantly higher than those in the remission group（0.75±0.24μg/g,138.52±63.28μg/g,103.25±45.63μg/g）, the differences were statistically significant (t=8.566 ～ 9.367, all P<0.05). The levels of stool S100A12（0.99±0.29μg/g），FC （188.94±70.94μg/g） and LF（142.31±63.21μg/g）in the mucosal lesion group were significantly higher than those in the mucosal healing group（0.48±0.21μg/g，82.17±33.61μg/g，59.56±20.52μg/g）, and the difference were statistically significant (t=7.295 ～ 8.458, all P<0.05). Pearson analysis showed that the levels of stool S100A12, FC and LF in patients with UC were positively correlated with the UCEIS score (r=0.426,0.438，0.417, all P<0.05). ROC analysis showed that stool S100A12, FC and LF had certain evaluation value for disease activity and mucosal healing of patients with UC, and the combined application of the three could effectively improve the evaluation value, the area under the curve for assessing disease activity was 0.895, the sensitivity and specificity were 88.70% and 90.28%, respectively. The area under the curve for assessing mucosal healing was 0.890, and the sensitivity and specificity were 91.18% and 86.84%, respectively. Conclusion　Stool S100A12, FC and LF combined application of disease activity and mucosal healing in patients with UC have a high evaluation value, and it has a certain clinical application value.

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备注/Memo

备注/Memo:
作者简介：杨思贤（1981-），女，硕士研究生，副主任医师，研究方向：消化系统相关疾病，E-mail：yangsixian897362@163.com。
更新日期/Last Update: 1900-01-01