[1]王方平,张平安,牛志立.固有免疫和适应性免疫与慢性丙肝的研究进展[J].现代检验医学杂志,2015,30(06):6-9.[doi:10.3969/j.issn.1671-7414.2015.06.002]
 WANG Fang-ping,ZHANG Ping-an,NIU Zhi-li.Studies about Innate and Adaptive Immune Responses on Chronic Hepatitis C[J].Journal of Modern Laboratory Medicine,2015,30(06):6-9.[doi:10.3969/j.issn.1671-7414.2015.06.002]
点击复制

固有免疫和适应性免疫与慢性丙肝的研究进展()
分享到:

《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年06期
页码:
6-9
栏目:
综述
出版日期:
2015-12-30

文章信息/Info

Title:
Studies about Innate and Adaptive Immune Responses on Chronic Hepatitis C
作者:
王方平张平安牛志立
武汉大学人民医院检验科,武汉430060
Author(s):
WANG Fang-pingZHANG Ping-anNIU Zhi-li
Department of Clinical Laboratory,Renmin Hospital of Wuhan University,Wuhan 430060,China
关键词:
慢性丙型肝炎固有免疫适应性免疫
分类号:
R392.11;R512.63
DOI:
10.3969/j.issn.1671-7414.2015.06.002
文献标志码:
A
摘要:
固有免疫应答是抵抗病毒入侵的第一道防线,启动后产生一系列的细胞因子如干扰素等发挥作用,6~8周后,适应性免疫应答才被检测到。经过抗原刺激后,活化、增殖的效应细胞如CD4+和CD8+T细胞、调节性T细胞和自然杀伤细胞,产生效应分子如抗体和细胞因子而发挥作用。虽然有固有免疫和适应性免疫应答机制,大多数丙型肝炎病毒感染者仍不能清除病毒,会发展为慢性持续性感染。该文就固有免疫和适应性免疫在慢性丙型肝炎发病机制中的作用进行综述。
Abstract:
Innate immune responses are the first line of defense against viral infections and after activated it would produce a series of cytokines such as interferon (IFN) to function.6~8 weeks later,the adaptive immune response can be detected.After being antigen stimulated,the effectors cells are activated and proliferated,such as CD4+and CD8+ T cells,Regulatory T cell,and generate effector molecules (such as antibodies,cytokines) to function.Although there are innate and adaptive immune responses mechanisms,most HCV-infected patients are still unable to clear the virus and develop viral persistence.In this review,summarize the role of innate immunity and adaptive immunity in chronic hepatitis C pathogenesis.

参考文献/References:

[1]Mohd Hanafiah K,Groeger J,Flaxman AD,et al.G-lobal epidemiology of hepatitis C virus infection:new estimates of age-specific antibody to HCV seroprevalence[J].Hepatology,2013,57(4):1333-1342.
[2]Aman W,Mousa S,Shiha G,et al.Current status and future directions in the management of chronic hepatitis C[J].Virology Journal,2012(9):57.
[3]Yang L,Seki E.Toll-Like receptors in liver fibrosis:cellular crosstalk and mechanisms[J].Front Physiol,2012(3):138.
[4]Park H,Serti E,Eke O,et al.IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection[J].Hepatology,2012,56(6):2060-2070.
[5]Takahashi K,Asabe S,Wieland S,et al.Plasmacytoid dendritic cells sense hepatitis C virus-infected cells,produce interferon,and inhibit infection[J].Proc Natl Acad Sci USA,2010,107(16):7431-7436.
[6]Mordstein M,Neugebauer E,Ditt V,et al.Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections[J].J Virol,2010,84(11):5670-5677.
[7]Gale M,Foy EM.Evasion of intracellular host defence by hepatitis C virus[J].Nature,2005,436(7053):939-945.
[8]Ketscher L,Hann BR,Morales DJ,et al.Selective inactivation of USP18 isopeptidase activity in vivo enhances ISG15 conjugation and viral resistance[J].Proc Natl Acad Sci USA,2015,112(5):1577-1582.
[9]Colonne PM,Sahni A,Sahni SK.Suppressor of cytokine signalling protein SOCS1 and UBP43 regulate the expression of type I interferon-stimulated genes in human microvascular endothelial cells infected with Rickettsia conorii[J].J Med Microbiol,2013,62(Pt 7):968-979.
[10]Sarasin-Filipowicz M,Wang XY,Yan M,et al.Alpha interferon induces long-lasting refractoriness of JAK-STAT signalling in the mouse liver through induction of USP18/UBP43[J].Mol Cell Biol,2009,29(17):4841-4851.
[11]Qi YF,Huang YX,Wang HY,et al.Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling[J].BMC Bioinformatics,2013(14):41.
[12]Schneider WM,Chevillotte MD,Rice CM.Interferon-stimulated genes:a complex web of host defenses[J].Annu Rev Immunol,2014(32):513-545.
[13]Thomas E,Gonzalez VD,Li Q,et al.HCV infection induces a unique hepatic innate immune response associated with robust production of type III interferons[J].Gastroenterology,2012,142(4):978-988.
[14]McGilvray I,Feld JJ,Chen L,et al.Hepatic cell-type specific gene expression better predicts HCV treatment outcome than IL28B genotype[J].Gastroenterology,2012,142(5):1122-1131.
[15]Sheahan T,Imanaka N,Marukian S,et al.Interferon lambda alleles predict innate antiviral immune responses and hepatitis C virus permissiveness[J].Cell Host Microbe,2014,15(2):190-202.
[16]Duong FH,Trincucci G,Boldanova T,et al.IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies[J].J Exp Med,2014,211(5):857-868.
[17]Cox AL,Mosbruger T,Lauer GM,et al.Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C[J].Hepatology,2005,42(1):104-112.
[18]Wahid A,Dubuisson J.Virus-neutralizing antibodies to hepatitis C virus[J].J Viral Hepat,2013,20(6):369-376.
[19]Neumann-Haefelin C,Thimme R.Adaptive immune responses in hepatitis C virus infection[J].Curr Top Microbiol Immunol,2013,369:243-262.
[20]Kared H,Fabre T,Bedard N,et al.Galectin-9 and IL-21 mediate cross-regulation between Th17 and Treg cells during acute hepatitis C[J].PLoS Pathog,2013,9(6):e1003422.
[21]Grakoui A,Shoukry NH,Woollard DJ,et al.HCV persistence and immune evasion in the absence of memory T cell help[J].Science,2003,302(5645):659-662.
[22]Kroy DC,Ciuffreda D,Cooperrider JH,et al.Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors[J].Gastroenterology,2014,146(2):550-561.
[23]Golden-Mason L,Palmer B,Klarquist J,et al.Upregulation of PD-1 expression on circulating and intrahepatic hepatitis C virus-specific CD8+ T cells associated with reversible immune dysfunction[J].J Virol,2007,81(17):9249-9258.
[24]Shin EC,Park SH,Nascimbeni M,et al.The frequency of CD127(+) hepatitis C virus (HCV)-specific T cells but not the expression of exhaustion markers predicts the outcome of acute HCV infection[J].J Virol,2013,87(8):4772-4777.
[25]Boettler T,Spangenberg HC,Neumann-Haefelin C,et al.T cells with a CD4+CD25+regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection[J].J Virol,2005,79(12):7860-7867.
[26]Abel M,Sene D,Pol S,et al.Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection[J].Hepatology,2006,44(6):1607-1616.
[27]Honegger JR, Kim S, Price AA,et al.Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses[J].Nat Med,2013,19(11):1529-1533.
[28]Falkowska E,Kajumo F,Garcia E,et al.Hepatitis C virus envelope glycoprotein E2 glycans modulate entry,CD81 binding,and neutralization[J].J Virol,2007,81(15):8072-8079.
[29]Brimacombe CL,Grove J,Meredith LW,et al.Neutralizing antibody-resistant hepatitis C virus cell-to-cell transmission[J].J Virol,2011,85(1):596-605.
[30]Seigel B,Bengsch B,Lohmann V,et al.Factors that determine the antiviral efficacy of HCV-specific CD8(+) T cells ex vivo[J].Gastroenterology,2013,144(2):426-436.

相似文献/References:

[1]邓刚,张平安.慢性丙型肝炎男性患者体内雌雄激素与抗黏病毒基因表达的关系[J].现代检验医学杂志,2015,30(05):53.[doi:10.3969/j.issn.1671-7414.2015.05.016]
 DENG Gang,ZHANG Ping-an.Role of Estrogen and Androgen on Gene Expression of Myxovirus Resistance A in Male Patients with Chronic Hepatitis C[J].Journal of Modern Laboratory Medicine,2015,30(06):53.[doi:10.3969/j.issn.1671-7414.2015.05.016]
[2]牛志立,张平安,童永清.探讨性别和年龄在慢性丙型肝炎患者 外周血Toll样受体3和7基因表达中的影响[J].现代检验医学杂志,2015,30(01):23.[doi:10.3969/j.issn.1671-7414.2015.01.007]
 NIU Zhi-li,ZHANG Ping-an,TONG Yong-qing.Exploring Impact of Gender and Age Discrepancies on the Expression of Toll-like Receptor 3 and 7 Gene mRNA of Patients with Chronic Hepatitis C Infection[J].Journal of Modern Laboratory Medicine,2015,30(06):23.[doi:10.3969/j.issn.1671-7414.2015.01.007]
[3]杨晓燕,张平安,牛志立,等.慢性丙型肝炎患者外周血单个核细胞中干扰素刺激基因及相关信号通路基因表达的研究[J].现代检验医学杂志,2017,32(03):18.[doi:10.3969/j.issn.1671-7414.2017.03.005]
 YANG Xiao-yan,ZHANG Ping-an,NIU Zhi-li,et al.Study on Expression Interferon Stimulating Gene and Related Signal Pathway Gene in Peripheral Blood Mononuclear Cells of Patients with Chronic Hepatitis C[J].Journal of Modern Laboratory Medicine,2017,32(06):18.[doi:10.3969/j.issn.1671-7414.2017.03.005]
[4]吴志美,袁建芬,徐 建,等.慢性丙型肝炎患者外周血CD3+CD16+56+NK细胞水平与肝纤维化指标相关性分析[J].现代检验医学杂志,2018,33(04):95.[doi:10.3969/j.issn.1671-7414.2018.04.025]
 WU Zhi-mei,YUAN Jian-fen,XU Jian,et al.Correlation Analysis of CD3+CD(16+56)+NK Cell Level in Peripheral Blood and Liver Fibrosis Index in Patients with Chronic Hepatitis C[J].Journal of Modern Laboratory Medicine,2018,33(06):95.[doi:10.3969/j.issn.1671-7414.2018.04.025]
[5]欧阳清慧,王 冰,杨自力,等.四川省绵阳地区慢性丙型肝炎患者继发2 型糖尿病危险因素分析[J].现代检验医学杂志,2020,35(04):151.[doi:10.3969/j.issn.1671-7414.2020.04.038]
 OUYANG Qing-hui,WANG Bing,YANG Zi-li,et al.Analysis of Risk factors of Chronic Hepatitis C Complicated with Type 2 Diabetes Mellitus in Mianyang of Sichuan[J].Journal of Modern Laboratory Medicine,2020,35(06):151.[doi:10.3969/j.issn.1671-7414.2020.04.038]

备注/Memo

备注/Memo:
作者简介:王方平(1989-),女,在读研究生,主要从事临床免疫学研究。 通讯作者:张平安,E-mail:zhangpingan@aliyun.com。
更新日期/Last Update: 1900-01-01