[1]齐进康,刘佳钰,刘 丹,等.类风湿关节炎患者血清25-OH-VD和SPP1水平检测的临床意义[J].现代检验医学杂志,2018,33(06):35-37+42.[doi:10.3969/j.issn.1671-7414.2018.06.009]
　QI Jin-kang,LIU Jia-yu,LIU Dan,et al.Study on Clinical Application of 25-Hydroxyvitamin D and Serum Osteopontin in Rheumatoid Arthritis[J].Journal of Modern Laboratory Medicine,2018,33(06):35-37+42.[doi:10.3969/j.issn.1671-7414.2018.06.009]
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类风湿关节炎患者血清25-OH-VD和SPP1水平检测的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年06期
页码:
35-37+42
栏目:
论著
出版日期:
2018-12-24

文章信息/Info

Title:
Study on Clinical Application of 25-Hydroxyvitamin D and Serum Osteopontin in Rheumatoid Arthritis
文章编号:
1671-7414(2018)06-035-04
作者:
齐进康1; 刘佳钰2; 刘 丹2; 曹团平2
1.西安市工人疗养院检验科,西安 710100; 2.西安市第五医院检验科,西安 710082
Author(s):
QI Jin-kang1; LIU Jia-yu2; LIU Dan2; CAO Tuan-ping2
1.Department of Clinical Laboratory,Xi'an Workers'Sanatorium,Xi'an 710100,China; 2.Department of Clinical Laboratory,the Fifth Hospital of Xi'an City,Xi'an 710082,China
关键词:
类风湿关节炎;  25-羟维生素D;  骨桥素1;  临床研究
分类号:
R593.22; R392.11
DOI:
10.3969/j.issn.1671-7414.2018.06.009
文献标志码:
A
摘要:
目的 探讨类风湿关节炎(RA)病程血清中25-羟维生素D(25-OH-VD)、血清骨桥素(SPP1)水平与疾病病情的意义。方法 2016年1月～2017年12月在西安市第五医院住院的RA患者96例为RA组,健康查体者60例为对照组。酶联免疫吸附试验(ELISA)法检测血清25-OH-VD和SPP1水平。结果 对照组与RA组血清25-OH-VD水平(34.62±7.27 ng/ml vs 16.22±2.53 ng/ml)差异有统计学意义(t=24.65,P=0.017),血清SPP1水平(33.12±4.38 ng/ml vs 56.71±9.60 ng/ml)差异也有统计学意义(t=19.87,P=0.014); RA组血清25-OH-VD与SPP1水平呈负相关(r=-0.39,P=0.034); RA组中病程小于5年与病程大于5年的血清25-OH-VD分别为20.11±2.54 ng/ml和12.77±2.39 ng/ml,差异有统计学意义(t=38.10,P=0.001); SPP1水平分别为53.27±12.31 ng/ml和61.71±8.63 ng/ml,差异有统计学意义(t=11.87,P=0.030)。结论 监测RA患者25-OH-VD和SPP1水平变化,对提示RA并发骨质疏松具有重要的临床意义。关注系统治疗疾病的同时给予维生素D的合理补充,尤其是长病程RA患者非常重要。
Abstract:
Objective To investigate the impact of the level of serum 25-OH-VD and osteopontin(SPP1)on the rheumatoid arthritis(RA)patients.Methods The levels of 25-OH-VD and SPP1 of 60 healthy controls and 96 patients with RA were detected by enzyme-linked immunosorbent assay(ELISA).Results The average concentration of25-OH-VD in healthy controls and RA patients was 34.62±7.2 ng/ml and 16.22±2.5 ng/ml respectively,and there was a significant difference between the two groups(t=24.65,P=0.017).The SPP1 concentration in healthy control group and RA group was 33.12±4.38 ng/ml and 56.71±9.60 ng/ml respectively,and there was significant difference between two groups(t=19.87,P=0.014).In 96 patients with RA,there were 64 patients with the course of RA less than5 years,accounting for 66.6% of the RA group,and the mean 25-OH-VD value was 20.11±2.54 ng/ml.There were 32 cases of RA patients with a course of RA more than 5 years,accounting for 33.3% in RA group,the average value of 25-OH-VD was 12.77±2.5 ng/ml,and the concentration of 25-OH-VD in patients with RA course less than 5 years was significantly different from those of patientswhose course was greater than 5 years(P<0.05).Conclusion There was a significant difference in the concentration of 25-OH-VD,SPP1 in RA patients with different course of RA.Clinicians should pay attentionto the rational supplement of vitamin D in the process of treatment of disease,especially for patients with long course of disease.In addition,need to monitor the 25-OH-VD and SPP1 level of RA patients and be alert to the possibility of osteoporosis.

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备注/Memo

备注/Memo:
基金项目:陕西省社会发展公关项目(2017SF-245); 陕西省自然科学基金(2015JM8483,2016JM8147); 陕西省中医药管理局科研项目(15-JC025,Lcms057); 西安市科技计划项目[201805096YX4SF30(14)]; 西安市中医药科研项目(2018年项目)。
作者简介:齐进康(1971-),男,主管检验师,主要从事生化分析,临床医学检验专业。
通讯作者:曹团平(1971-),男,本科,副主任技师,主要从事临床检验工作,E-mail:13072969053@163.com。
更新日期/Last Update: 2018-11-30