[1]张 微,张润清,于 磊.类风湿关节炎并发贫血女性患者血清铁蛋白检测的临床价值[J].现代检验医学杂志,2018,33(02):118-120,124.[doi:10.3969/j.issn.1671-7414.2018.02.001]
　ZHANG Wei,ZHANG Run-qing,YU Lei.Clinical Value of Serum Ferritin Detection in Patients with Rheumatoid Arthritis Complicated with Anemia[J].Journal of Modern Laboratory Medicine,2018,33(02):118-120,124.[doi:10.3969/j.issn.1671-7414.2018.02.001]
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类风湿关节炎并发贫血女性患者血清铁蛋白检测的临床价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年02期
页码:
118-120,124
栏目:
检验与临床
出版日期:
2018-04-05

文章信息/Info

Title:
Clinical Value of Serum Ferritin Detection in Patients with Rheumatoid Arthritis Complicated with Anemia
文章编号:
1671-7414(2018)02-118-04
作者:
张 微1; 张润清1; 于 磊2
1.北京市昌平区中西医结合医院,北京 102208; 2.国家卫计委科学技术研究所,北京 100081
Author(s):
ZHANG Wei1; ZHANG Run-qing1; YU Lei2
1.Beijing Changping Hospital of Integrated Chinese and WesternMedicine,Beijing 102208, China; 2.National Research Institute for Health and Family Planning,Beijing 100081,China
关键词:
类风湿关节炎;  贫血;  铁蛋白
分类号:
R593.22; R446.112
DOI:
10.3969/j.issn.1671-7414.2018.02.001
文献标志码:
A
摘要:
目的 探索类风湿关节炎(RA)并发贫血女性患者血清铁蛋白(sFt)检测的临床价值。方法 选取2014年1月～2016年12月在北京市昌平区中西医结合医院就诊的RA女性患者,排除其他自身免疫性疾病、严重肝肾疾病、炎症感染及恶性肿瘤,纳入154例作为研究对象,记录体格检查和实验室检查结果,并进行活动指标评估。同时选取60例年龄匹配的健康体检者作为参考组。根据贫血状态和血清铁蛋白水平比较各组RA相关指标、铁代谢指标和并发症结果,进行统计学分析。结果 RA并发贫血患者较不并发贫血患者的体质指数低(BMI)(22.69±3.89 kg/m2 vs24.51±3.61 kg/m2,t=-3.39,P<0.001),血清铁(Fe)[9.95(7.75)μmol/Lvs 13.30(7.80)μmol/L,F=-1.98,P<0.001]、总铁结合力(TIBC)[21.75(18.55)μmol/L vs 31.40(15.60)μmol/L,F=-1.72,P=0.001]水平低,差异均有统计学意义。而RA活动度评分(DAS28)以及各项活动度指标都显著高于不并发贫血患者组,差异均有统计学意义(F=-1.71～2.14,P<0.05),但是两组间sFt水平差异无统计学意义(F=0.24,P=0.659)。RA并发贫血的患者组,高sFt水平组患者红细胞沉降率(ESR)显著升高[59(53)mm/h vs 29(43)mm/h,F=-4.35,P<0.001],并具有较高的血脂水平,高血压、糖尿病、心血管疾病、骨质疏松和高脂血症的发生率也较高,但差异无统计学意义。结论 RA并发贫血会加重患者病情,sFt可以用于辅助RA并发贫血患者的诊断和治疗,监控RA并发症的发生。
Abstract:
Abstract:Objective To explore the clinical value of serum ferritin(sFt)detection in patients with rheumatoid arthritis(RA)complicated with anemia.Methods From January 2014 to December 2016,154 female RA patients hospitalized at Beijing Changping Hospital of Integrated Chinese and Western Medicine were enrolled and patients without other autoimmune diseases,severe liver and kidney disease,inflammatory infections and malignant tumors were excluded.At the same time,60 age-matched healthy physical examination were selected as a reference.The two groups were generally recordedphysical examination,laboratory tests and activity index assessment.Comparisonof the results of each group for statistical processing.Results The body mass index(BMI)of patients with anemia complicated with anemia(22.69±3.89 kg/m2 vs 24.51±3.61 kg/m2,t=-3.39,P<0.001)andserum iron [9.95(7.75)μmol/L vs 13.30(7.80)μmol/L,F=-1.98,P<0.001].However,the RA activity score(DAS28)and various activity indexes were significantly higher than those of non-concurrent anemia(F=1.71～2.14,all P<0.05).However,there was no significant difference in sFt levelsbetween the two groups(F=0.24,P=0.659).Patients with RA complicated with anemia had significantly higher ESR in patients with high sFt levels [29(43)mm/h vs 59(53)mm/h,F=-4.35,P<0.001] and had higher serum lipids,hypertension,diabetes.The incidence of cardiovascular disease,osteoporosis and hyperlipidemia was also higher,but the difference was not statistically significant.Conclusion RA complicated with anemia could aggravate the patient's condition.sFt may be used to assist the diagnosis and treatment of patients with RA complicated with anemia and monitor the occurrence of RA complications.

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备注/Memo

备注/Memo:
作者简介:张 微(1982-),女,本科,主管检验师,研究方向:临床医学检验与实验室管理,E-mail:2293658713@qq.com。 通讯作者:于 磊(1979-),E-mail:652558575@qq.com。
更新日期/Last Update: 2018-04-16