[1]闫美田,郑雨桐,孙艳美,等.新型冠状病毒肺炎患者血液CRP, CREA, ALB, IL-6 水平检测对疾病预后的应用价值分析[J].现代检验医学杂志,2020,35(05):106-109.[doi:10.3969/j.issn.1671-7414.2020.05.027]
　YAN Mei-tian,ZHENG Yu-tong,SUN Yan-mei,et al.Analysis of the Value of Detection of Blood CRP,CREA,ALB and IL-6 Level in Patients with New Coronavirus Pneumonia to the Prognosis of the Disease[J].Journal of Modern Laboratory Medicine,2020,35(05):106-109.[doi:10.3969/j.issn.1671-7414.2020.05.027]
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新型冠状病毒肺炎患者血液CRP, CREA, ALB, IL-6 水平检测对疾病预后的应用价值分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年05期
页码:
106-109
栏目:
新型冠状病毒肺炎检验专题
出版日期:
2020-11-01

文章信息/Info

Title:
Analysis of the Value of Detection of Blood CRP,CREA,ALB and IL-6 Level in Patients with New Coronavirus Pneumonia to the Prognosis of the Disease
文章编号:
1671-7414（2020）05-106-04
作者:
闫美田1; 2; 郑雨桐1; 2; 孙艳美3; 栾亮2; 刘静2; 田笑2; 万楠2
1. 大连医科大学，辽宁大连 116044；2. 北部战区总医院检验科，沈阳 110016； 3. 吉林医药学院，吉林吉林 132013
Author(s):
YAN Mei-tian1; 2; ZHENG Yu-tong1; 2; SUN Yan-mei3; LUAN Liang2;  LIU Jing2; TIAN Xiao2; WAN Nan2
1.Dalian Medical University,Liaoning Dalian 116044,China;2.Department of Clinical Laboratory, Northern Theater General Hospital, Shenyang 110016,China;3.Jilin Medical College,Jilin Jilin 132013,China
关键词:
新型冠状病毒肺炎; C 反应蛋白; 肌酐; 清蛋白; 白细胞介素6
分类号:
R373.19；R446.11
DOI:
10.3969/j.issn.1671-7414.2020.05.027
文献标志码:
A
摘要:
目的　探讨性别、年龄以及血液指标联合检测在预测新型冠状病毒肺炎（COVID-19）患者预后的应用价值。 方法　选择2020 年2~3 月在泰康同济（武汉）医院的145 例COVID-19 确诊患者，根据出院预后状况分为治愈组（130 例）和死亡组（15 例），对两组患者的性别、年龄及血液中淋巴细胞绝对值（LYMPH）、C 反应蛋白（CRP）、肌酸 激酶MB 同工酶（CK-MB）、肌酐（CREA）、清蛋白（ALB）、白细胞介素6（IL-6）和降钙素原（PCT）表达水平 进行比较。应用多因素logistic 回归分析和受试者工作曲线（ROC 曲线）评价相关检测指标对COVID-19 预后的判断价值。 结果　治愈组、死亡组患者性别之间差异无统计学意义（χ ２=0.412，P ＞ 0.05）, 年龄之间差异有统计学意义（t =-4.341, P ＜ 0.05）, LYMPH，CRP，CK-MB，CREA，ALB，IL-6 和PCT 之间差异均有统计学意义（U =97.000~1 907.000, 均 P ＜ 0.05），而经多因素logistic 回归分析仅筛选出CRP，CREA，ALB 和IL-6 四项是死亡的独立危险因素。CRP， CREA，ALB，IL-6 以及CRP+CREA+ALB+IL-6 联合检测的ROC 曲线下面积（AUC 值）分别为0.978，0.881，0.950， 0.979 和0.988，敏感度分别为100%，86.7%，91.5%，100% 和100%，特异度分别为93.8%，84.6%，86.7%，88.5% 和 95.4%。 结论　CRP，CREA，ALB 和IL-6 可以作为COVID-19 患者预后的判断指标，CRP+ALB+CRP+CREA 联合检 测能够提高COVID-19 患者预后的评估能力。
Abstract:
Objective　To explore the value of sex, age and blood indexes in predicting the prognosis of patients with COVID-19. Methods　A total of 145 patients diagnosed with COVID-19 in Taikang Tongji (Wuhan) Hospital from February to March in 2020 were selected. They were divided into cure group (n=130) and death group (n =15) according to the prognosis of discharge. The sex, age and the expression levels of lymphocyte absolute value (LYMPH), C-reactive protein (CRP), creatine kinase MB isoenzyme (CK-MB), creatinine (CREA), albumin (ALB), interleukin6 (IL-6) and procalcitonin (PCT) in blood were compared between the two groups.Multivariate logistic regression analysis and receiver working curve (ROC curve) were used to evaluate the prognostic value of related indexes in COVID-19. Results　The differences in sex between the two groups were not statistically significant(χ ２=0.412，P>0.05).The differences in ages between the two groups were statistically significant(t = - 4.341, P>0.05). The differences in LYMPH, CRP, CK-MB, CREA, ALB, IL-6 and PCT between the two groups were statistically significant(U =97.000~1 907.000, all P <0.05). Only CRP, CREA, ALB and IL-6 were independent risk factors of death by multivariate logistic regression analysis.The area under the ROC curve (AUC value) of CRP, CREA, ALB, IL-6 and CRP+CREA+ALB+IL-6 were 0.978，0.881，0.950，0.979 and 0.988，the sensitivity were 100%，86.7%，91.5%，100% and 100%, and the specificity were 93.8%, 84.6%, 86.7%, 88.5% and 95.4%, respectively. Conclusion　CRP, CREA, ALB and IL-6 can be used as prognostic indicators in patients with COVID-19. Combined detection of CRP+ALB+CRP+CREA can improve the ability to evaluate the prognosis of patients with COVID-19.

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备注/Memo

备注/Memo:
基金项目：辽宁省自然基金资助（2019-ZD-1027）。
作者简介：闫美田（1993-），女，在读研究生，研究方向：病原生物与分子生物学，E-mail：ymt19930425@163.com。
通讯作者：万楠（1978-），男，副主任技师，硕士生导师，E-mail：wannan@outlook.com。
更新日期/Last Update: 2020-10-30