[1]王跃帮,吴 娟,崔 倩,等.IL-6基因启动子区域-572C>G和-174G>C多态性与江苏宿迁汉族人群冠心病的相关性[J].现代检验医学杂志,2018,33(03):31-34.[doi:10.3969/j.issn.1671-7414.2018.03.010]
　WANG Yue-bang,WU Juan,CUI Qian,et al.Association between Interleukin-6-572C>G and -174G>C Gene Polymorphism in the Promoter Region and Coronary Heart Disease of Han Population in Suqian of Jiangsu[J].Journal of Modern Laboratory Medicine,2018,33(03):31-34.[doi:10.3969/j.issn.1671-7414.2018.03.010]
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IL-6基因启动子区域-572C>G和-174G>C多态性与江苏宿迁汉族人群冠心病的相关性()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年03期
页码:
31-34
栏目:
论著
出版日期:
2018-07-17

文章信息/Info

Title:
Association between Interleukin-6-572C>G and -174G>C Gene Polymorphism in the Promoter Region and Coronary Heart Disease of Han Population in Suqian of Jiangsu
文章编号:
1671-7414(2018)03-031-04
作者:
王跃帮; 吴 娟; 崔 倩; 王 飞; 常珊碧
宿迁市第一人民医院检验科,江苏宿迁 223800
Author(s):
WANG Yue-bang; WU Juan; CUI Qian; WANG Fei; CHANG Shan-bi
Department of Clinical Laboratory,Suqian First People's Hospital,Jiangsu Suqian 223800,China
关键词:
冠心病;  白细胞介素-6;  基因多态性
分类号:
R541.4; Q786
DOI:
10.3969/j.issn.1671-7414.2018.03.010
文献标志码:
A
摘要:
目的 探讨白细胞介素6(interleukin-6,IL-6)基因启动子区域-572C>G和-174G>C基因多态性与宿迁汉族人群冠心病(coronary heart disease,CHD)的关系。方法 参考2010卫生部CHD诊断标准(WS319-2010),选择2017年1～12月在宿迁市第一人民医院心内科确诊的CHD患者,应用聚合酶链-限制性片段长度多态性(Polymerase chain reaction-restriction fragment length polymorphism,PCR-RFLP)方法检测266例CHD患者和192例体检健康人群(对照组),分析其IL-6-572C>G和IL-6-174G>C基因多态性,并进行Hardy-Weinberg平衡检验,检测血糖、血脂等生化指标。结果 IL-6-572C>G基因型和等位基因频率在两组间分布差异有统计学意义(χ2=11.1,19.5,22.4,均P<0.05),CHD组GG型和CG型OR值分别是CC型的4.88倍(95%CI:2.31～10.31)和1.96倍(95% CI:1.32～2.91); -174G>C基因型和等位基因频率在两组间分布差异无统计学意义(χ2=0.024,0.027,均P>0.05)。结论 IL-6-572G等位基因可能是宿迁汉族CHD的易感基因,IL-6-174G>C基因多态性可能与宿迁汉族人群CHD没有相关性。
Abstract:
Abstract:Objective To investigate therelationship of interleukin 6(IL-6)gene promoter region upstream of the -572C>G and -174G>C gene polymorphism with coronary heart disease(CHD)of han population in Suqian ofJiangsu.Methods Reference 2010 CHD diagnostic criteria of the Ministry of Health(WS319-2010),detecting the polymorphism of IL-6-572C>G and -174G>C gene polymorphism in 266 CHD patients and 192 healthy population by polymerase chain restriction fragment length polymorphism(PCR-RFLP)and Hardy-Weinberg equilibrium was tested,measuring the concentration of blood sugar,lipid.Results At IL-6-572C>G,the OR about GG and type CG in CHD group were CC 4.88 times(95% CI:2.31～10.31)and 1.96times(95% CI:1.32～2.91)respectively.The difference of genotype and alleles werestatistical significance between the two groups(χ2=11.1,19.5 and 22.4,all P<0.05).At IL-6-174C>G,the difference of genotype and alleles were no statistical significance between the two groups(χ2=0.024 and 0.027,all P>0.05).Conclusion IL-6-572G allele may be a susceptible gene of CHD in Han population in Suqian.However IL-6-174G>C gene polymorphism is not related to CHD Han population in Suqian.

参考文献/References:

[1] 陈伟伟,高润霖,刘力生,等.《中国心血管病报告2015》概要[J].中国循环杂志,2016,31(6):521-528. Chen WW,Gao RL,Liu LS,et al.Chinese cardiovascular disease report 2015[J].Chinese Circulation Journal,2016,31(6):521-528.
[2] Momiyama Y,Adachi H,Fairweather DL,et al.Introductory editorial-inflammation,atherosclerosis and coronary artery disease[J].New England Journal of Medicine,2016,352(16):1685-1695.
[3] Liu SL,Yin YW,Sun QQ,et al.Genetic polymorphisms of interleukin-6 gene and susceptibility to coronary artery disease in Chinese population:Evidencebased on 4 582 subjects[J].Human Immunology,2015,76(7):505-510.
[4] Chae J,Ng T,Hui LY,et al.Impact of TNF-α(rs1800629)and IL-6(rs1800795)polymorphisms on cognitive impairment in Asian breast cancer patients[J].PLoS One,2016,11(10):e0164204.
[5] 陈 丹,张 葵,魏红霞,等.IL-6基因-572C/G多态性与江苏宿迁地区汉族人群冠心病的关系[J].临床检验杂志,2016,34(5):366-370. Chen D,Zhang K,Wei HX,et al.Association between interleukin-6 gene-572C/G polymorphism and coronary heart disease in Han population of Suqiancity,Jiangsu province,China[J].Chinese Journal of Clinical Laboratory Science,2016,34(5):366-370.
[6] 刘永玲,罗厚龙,刘行超,等.血清SOD和hsCRP等指标在急性冠脉综合征中的应用及相关性分析[J].现代检验医学杂志,2017,32(6):115-117,121. Liu YL,Luo HL,Liu XC,et al.Level and correlationship of serum SOD and hsCRP and other indicators in acute coronary syndrome[J].Journal of Modern Laboratory Medicine,2017,32(6):115-117,121.
[7] 姚创利,黎 阳,鲁旭娟,等.超氧化物歧化酶及其同工酶和超敏C-反应蛋白与冠心病的关系[J].现代检验医学杂志,2016,31(5):73-75. Yao CL,Li Y,Lu XJ,et al.Relationship of superoxide dismutase isoenzyme and high sensitive C-reactive protein with coronary heart disease[J].Journal of Modern Laboratory Medicine,2016,31(5):73-75.
[8] 王伊林,崔晓雪,于 焱,等.白细胞介素在动脉粥样硬化发病中的作用研究进展[J].检验医学与临床,2016,13(Z1):310-312. Wang YL,Cui XX,Yu Y,et al.Research progress of the role of interleukin in atherosclerosis[J].Laboratory Medicine and Clinic,2016,13(Z1):310-312.
[9] Li L,Li E,Zhang LH,et al.IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease[J].Genetics &Molecular Research Gmr,2015,14(3):8451-8547.
[10] Mao L,Geng GY,Han WJ,et al.Interleukin-6(IL-6)-174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population[J].Genetics & Molecular Research Gmr,2016,15(2)doi:10.4238/gmr.15027803.
[11] Bhanushali AA,Das BR.Promoter variants in interleukin-6 and tumor necrosis factor alpha and risk of coronary artery disease in a population from Western India[J].Indian J Hum Genet,2013,19(4):430-436.
[12] 梁丽丽,蔡梦云,周萌媛,等.CTRP9基因多态性与冠心病的相关性[J].中国老年学杂志,2017,37(1):67-70. Liang LL,Cai MY,Zhou MY,et al.Association of CTRP 9 gene polymorphismwith coronary heart disease[J].Chinese Journal of Gerontology,2017,37(1):67-70.

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备注/Memo

备注/Memo:
作者简介:王跃帮(1984-),男,硕士,主管技师,主要从事临床生化检验,E-mail:jssqwyb@sohu.com。 通讯作者:常珊碧(1984-),女,硕士在读,主管技师,E-mail:330667489@qq.com。
更新日期/Last Update: 2018-04-16