[1]王结珍,梁培松,王伟佳,等.系统性红斑狼疮患者外周血RDW-CV和PLT/NEUT%与相关免疫学指标及病情活动度的相关性[J].现代检验医学杂志,2019,34(03):131-133,136.[doi:10.3969/j.issn.1671-7414.2019.03.033]
　WANG Jie-zhen,LIANG Pei-song,WANG Wei-jia,et al.Correlation Analysis of Peripheral Blood RDW-CV,PLT/NEUT%,Related Immunological Indexes and Disease Activityin Systemic Lupus Erythematosus Patients[J].Journal of Modern Laboratory Medicine,2019,34(03):131-133,136.[doi:10.3969/j.issn.1671-7414.2019.03.033]
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系统性红斑狼疮患者外周血RDW-CV和PLT/NEUT%与相关免疫学指标及病情活动度的相关性()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年03期
页码:
131-133,136
栏目:
检验与临床
出版日期:
2019-06-20

文章信息/Info

Title:
Correlation Analysis of Peripheral Blood RDW-CV,PLT/NEUT%,Related Immunological Indexes and Disease Activityin Systemic Lupus Erythematosus Patients
文章编号:
1671-7414(2019)02-131-04
作者:
王结珍,梁培松,王伟佳,梁艮英
(中山大学附属中山市人民医院检验医学中心,广东中山 528403)
Author(s):
WANG Jie-zhen,LIANG Pei-song,WANG Wei-jia,LIANGGen-ying
(Department of Clinical Laboratory,the People's Hospital of Zhongshan City,Affiliated of Sun Yat-sen University,Guangdong Zhongshan 528403,China)
关键词:
红细胞分布宽度;  血小板;  中性粒细胞百分比;  系统性红斑狼疮
分类号:
R593.241; R392.11
DOI:
10.3969/j.issn.1671-7414.2019.03.033
文献标志码:
A
摘要:
目的 探讨红细胞分布宽度变异系数(RDW-CV)和血小板与中性粒细胞百分比比值(PLT/NEUT%)与系统性红斑狼疮(SLE)相关免疫学指标及病情活动度的相关性。方法 回顾性分析128例SLE患者与128例健康对照的资料; 比较两组RDW-CV和PLT/NEUT%水平,分析RDW-CV和PLT/NEUT%与CRP,ESR,C3,C4,IgG和SLEDAI-2000的相关性; 评价RDW-CV,PLT/NEUT%及两者联合检测在诊断SLE疾病的价值。结果 SLE组PLT/NEUT%水平低于对照组,而RDW-CV水平高于对照组; PLT/NEUT%与CRP,ESR和IgG呈负相关(r=-0.258～-0.245,均P<0.01); 与C3和C4呈正相关(r=0.507,0.309,均P<0.01); RDW-CV与CRP,ESR呈正相关(r=0.391,0.306,均P<0.01),与C3呈负相关(r=-0.236,P:0.07); RDW,PLT/NEUT%和C3与SLEDAI-2000有线性回归关系(t=-5.819～3.075,均P<0.01); 两者联合预测值(AUC=0.879)>PLT/NEUT%(AUC=0.861)>RDW-CV(AUC=0.784)。结论 RDW-CV和PLT/NEUT%可作为SLE病情变化的辅助监测指标,与SLE疾病活动度有一定的相关性。
Abstract:
Objective To evaluate the correlation of coefficient of variation of red blood cell distribution width(RDW-CV),platelet(PLT)to proportion of neutrophils(NEUT%),related immunological indexes and diseaseactivity in systemic lupus erythematosus patients.Methods The medical records of 128 SLE patients and 128 healthy controls were retrospectively reviewed.The level of RDW-CV and PLT/NEUT% were compared between twogroups.The correlation among RDW-CV,PLT/NEUT%,CRP,ESR,C3,C4,IgG and SLEDAI-2000 were analyzed,and the value of RDW-CV,PLT/NEUT% and the both in diagnosis of SLE disease were evaluated.Results The level of PLT/NEUT% in SLE group was significantly lower than that in healthy controls,and the level of RDW-CV in SLE group was significantly higher than that in healthy controls; PLT/NEUT% was negatively correlated with CRP,ESR and IgG(r=-0.256,-0.258,-0.245,all P<0.01),but was positively correlated with C3and C4.RDW-CV was positively correlated with CRP,ESR(r=0.391,0.306,all P<0.01),but was negatively correlated with C3(r=-0.236,P=0.07).RDW-CV,PLT/NEUT% and C3 had linear regression relation ship with SLEDAI-2000(t=5.819～3.075,P<0.01),and the predictive value of two combined(AUC=0.868)>PLT/NEUT%(AUC=0.858)>RDW-CV(AUC=0.787).ConclusionRDW-CV and PLT/NEUT% can be used as auxiliary monitoring indexes of SLE condition changed, has certain correlation with SLE disease activity.

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备注/Memo

备注/Memo:
作者简介:王结珍(1985-),女,本科,主管技师,专业:临床检验,E-mail:wanglei8511@163.com。 收稿日期:2018-11-17 修回日期:2018-12-28
更新日期/Last Update: 2019-06-20