[1]罗　金,蓝柳萍.血液RDW，Hcy 和NEFA 水平联合检测在冠心病诊断中的应用[J].现代检验医学杂志,2020,35(03):62-65.[doi:10.3969 ／ j.issn.1671-7414.2020.03.015]
　LUO Jin,LAN Liu-ping.Application of Combined Detection of Blood RDW, Hcy and NEFA Levels in the Diagnosis of Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2020,35(03):62-65.[doi:10.3969 ／ j.issn.1671-7414.2020.03.015]
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血液RDW，Hcy 和NEFA 水平联合检测在冠心病诊断中的应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年03期
页码:
62-65
栏目:
论著
出版日期:
2020-07-20

文章信息/Info

Title:
Application of Combined Detection of Blood RDW, Hcy and NEFA Levels in the Diagnosis of Coronary Heart Disease
文章编号:
1671-7414（2020）03-062-05
作者:
罗　金1; 蓝柳萍2
（1. 玉林市第二人民医院检验科，广西玉林　537000；2. 玉林市卫生学校，广西玉林　537000）
Author(s):
LUO Jin1;  LAN Liu-ping2
（1. Department of Laboratory Medicine, the Second People’s Hospital of Yulin, Guangxi Yulin 537000, China; 2. Yulin Health School, Guangxi Yulin 537000, China）
关键词:
冠心病; 红细胞体积分布宽度; 同型半胱氨酸; 游离脂肪酸
分类号:
R541.4；R446.11
DOI:
10.3969 ／ j.issn.1671-7414.2020.03.015
摘要:
目的　探讨红细胞体积分布宽度（RDW）、同型半胱氨酸（Hcy）和游离脂肪酸（NEFA）联合检测在冠心病 （CHD）诊断中的应用价值。方法　选取2019 年1~7 月在玉林市第二人民医院住院治疗的CHD 患者162 例，同期选 取健康体检者131 例作为对照组。比较两组研究对象的RDW，Hcy 和NEFA 水平差异，采用受试者工作特征（ROC） 曲线分析各指标对CHD的诊断价值。结果　①CHD组RDW(%)，Hcy(μmol/L) 和NEFA(mmol/L) 水平分别是13.2（12.50， 14.40），12.45（10.28，15.70）和0.50（0.35，0.65），高于对照组[12.7（12.10，13.20），6.50（5.67，8.07），0.34 （0.28，0.40）]，差异均有统计学意义（F=-5.298, -11.411, -7.035, 均P ＜ 0.01）。② ROC 曲线下面积对冠心病诊断价 值的排序为RDW+Hcy+NEFA>Hcy>NEFA>RDW, RDW 的敏感度为35.2%，特异度为94.7%；Hcy 的敏感度是94,4%， 特异度为77.1%；NEFA 的敏感度为66.7%，特异度为77.9%。RDW+Hcy+ NEFA 联合检测敏感度提高至96.3%。结论　 RDW，Hcy 和NEFA 联合检测可以提高对CHD 的诊断效能，对CHD 诊断具有较高的临床应用价值。
Abstract:
Objective　To explore the application value of combined detection of red blood cell volume distribution width (RDW), homocysteine (Hcy) and nonestesterified fatty acid (NEFA) in the diagnosis of coronary heart disease (CHD). Methods　From January 2019 to July 162 CHD patients who were hospitalized in the Second People’s Hospital of Yulin were selected, and 131 healthy subjects were selected as the control group. The differences in RDW, Hcy and NEFA levels between the two groups of subjects were detected. The diagnostic value of each index on CHD was analyzed by the receiver operating characteristic (ROC) curve. Results　① The RDW(%), Hcy (μmol/L) and NEFA(mmol/L) levels in the CHD group were 13.2 (12.50, 14.40), 12.45 (10.28, 15.70) and 0.50(0.35, 0.65), which were higher than those in the control group [12.7 (12.10, 13.20) , 6.50 (5.67, 8.07), 0.34(0.28, 0.40)], the differences were statistically significant (F=-5.298,-11.411,-7.035,P <0.01). ② The order of the area under the ROC curve for the diagnosis of coronary heart disease was RDW + Hcy + NEFA> Hcy> NEFA> RDW, the sensitivity of RDW was 35.2%, and the specificity was 94.7%, respectively. The sensitivity of Hcy was 94.4%, and specificity was 77.1%. The sensitivity of NEFA was 66.7%, and the specificity was 77.9%. The sensitivity of RDW + Hcy + NEFA combined detection was increased to 96.3%. Conclusion　The combined detection of RDW, Hcy and NEFA can improve the diagnostic efficacy of CHD, and has higher clinical application value for the diagnosis of CHD.

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备注/Memo

备注/Memo:
收稿日期：2019-12-12　修回日期：2019-12-26作者简介：罗金（1984-），男，大学本科，主管检验师，专业：生化检验，E-mail:261781048@qq.com
更新日期/Last Update: 2020-07-20