[1]屈慧,李娅,黄瑶楠,等.心力衰竭患者外周血RDW 和NT-pro-BNP 联合检测对临床诊断及分级的相关性研究[J].现代检验医学杂志,2020,35(05):65-67,72.[doi:10.3969/j.issn.1671-7414.2020.05.017]
　QU Hui,LI Ya,HUANG Yao-nan,et al.Correlation Study on the Combined Detection of RDW and NT-Pro-BNP in Patients with Heart Failure to Clinical Diagnosis and Grading[J].Journal of Modern Laboratory Medicine,2020,35(05):65-67,72.[doi:10.3969/j.issn.1671-7414.2020.05.017]
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心力衰竭患者外周血RDW 和NT-pro-BNP 联合检测对临床诊断及分级的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年05期
页码:
65-67,72
栏目:
论著
出版日期:
2020-11-01

文章信息/Info

Title:
Correlation Study on the Combined Detection of RDW and NT-Pro-BNP in Patients with Heart Failure to Clinical Diagnosis and Grading
文章编号:
1671-7414（2020）05-065-04
作者:
屈慧1; 李娅2; 黄瑶楠1; 原晓庆1; 皇海1
1. 空军军医大学第一附属医院全军临床检验医学研究所，西安 710032；2. 西安市第四医院检验科，西安 710004
Author(s):
QU Hui1; LI Ya2; HUANG Yao-nan1; YUAN Xiao-qing1; HUANG Hai1
1.Institute of Clinical Laboratory Medicine of People’s Liberation Army, the First Affiliated Hospital of AFMU,Xi’an 710032,China;2.Department of Clinical Laboratory,the Fourth Hospital of Xi’an, Xi’an 710004,China
关键词:
心力衰竭; 红细胞体积分布宽度; N 末端B 型脑钠肽前体
分类号:
R541.6；R446.11
DOI:
10.3969/j.issn.1671-7414.2020.05.017
文献标志码:
A
摘要:
目的　探讨心力衰竭(heart failure,HF) 患者外周血红细胞体积分布宽度（red blood cell distribution width, RDW）和N 末端B 型脑钠肽前体（NT-pro-BNP）联合检测对HF 临床诊断及分级的相关性研究。方法　选择80 例HF 确诊患者和100 例健康体检者，采用Sysmex 全自动血细胞分析仪进行全血RDW 检测分析；采用电化学发光法检测血 清NT-pro-BNP 水平，运用SPSS17.0 软件对结果进行数据分析。结果　HF 确诊患者血中RDW 和NT-pro-BNP 的水平 明显高于健康对照者，差异有统计学意义（P ＜ 0.05）；NYHA 分级Ⅳ级患者血中RDW 和NT-pro-BNP 的水平显著高 于NYHA 分级Ⅰ～Ⅱ级和Ⅲ级患者，其差异具有统计学意义（P ＜ 0.05）。NYHA 分级Ⅲ级患者血中RDW 和NT-pro- BNP 的水平显著高于NYHA 分级Ⅰ～Ⅱ级患者，其差异具有统计学意义（P ＜ 0.05）。三组不同NYHA 分级HF 患者 血中NT-pro-BNP 和RDW 水平呈正相关关系（r = 0.554，P=0.01）；Pearson 相关分析显示RDW 与NT-pro-BNP 水平 呈正相关（r = 0.554，P = 0.01）。结论　RDW 和NT-pro-BNP 水平的联合检测可提高HF 的临床快速诊断率，为HF 诊 断、病程判断和预后提供诊断依据。
Abstract:
Objective　To investigate the combined detection of red blood cell volume distribution width (RDW) and N-terminal B-type brain natriuretic peptide precurso (NT-pro-BNP) in patients with heart failure(HF) to clinical diagnosis and grading. Methods　80 patients with heart failure and 100 healthy people were selected to detect RDW in whole blood by Sysmex automatic hematology analyzer, and NT-Pro-BNP in serum was detected by electrochemiluminescence.SPSS17.0 software was used to analyze the data. Results　The levels of RDW and NT-pro-BNP in patients with heart failure were significantly higher than those in healthy controls, and the difference was statistically significant (P<0.05).The levels of RDW and NT-pro- BNP in patients with NYHA grade Ⅳ were significantly higher than those of patients with NYHA grade Ⅰ～Ⅱ and Ⅲ，and the difference was statistically significant (P<0.05). The levels of RDW and NT-pro-BNP in patients with NYHA grade Ⅲ were significantly higher than those of patients with NYHA grade Ⅰ～Ⅱ，and the difference was statistically significant (P<0.05). There was a positive correlation between NT-pro-BNP and RDW levels in three groups of HF patients with different NYHA grades (r = 0.554, P = 0.01). Pearson correlation analysis showed that RDW was positively correlated with NT-pro-BNP (r = 0.554, P = 0.01). Conclusion　The combined detection of RDW and NT pro-BNP can improve the clinical diagnosis rate of HF and provide the diagnosis basis for HF diagnosis, course judgment and prognosis.

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备注/Memo

备注/Memo:
基金项目：陕西省科技厅(2017SF-265) ，一般项目- 社会发展领域: 双歧杆菌联合HSV-1 TK/GCV 共同抑制胃癌的研究。
作者简介：屈慧（1986-）女，主管技师，主要研究方向：急诊检验与急性疾病的相关性，以及血细胞临床检测应用及其形态学观察， 　　　　　E-mail:quhui1113@163.com。
通讯作者：皇海(1971-)，男，硕士研究生，研究方向：急诊检验，E-mail:huanghai110728@163.com。
更新日期/Last Update: 2020-10-30