[1]陈青文,李丹丹.冠心病患者外周血中性粒细胞 / 淋巴细胞比值与冠脉狭窄程度的相关性研究[J].现代检验医学杂志,2020,35(06):98-101.[doi:doi:10.3969/j.issn.1671-7414.2020.06.024]
　CHEN Qing-wen,LI Dan-dan.Correlation between the Degree of Coronary Stenosis and the Neutrophil/Lymphocyte Ratio in Patients with Coronary Artery Disease[J].Journal of Modern Laboratory Medicine,2020,35(06):98-101.[doi:doi:10.3969/j.issn.1671-7414.2020.06.024]
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冠心病患者外周血中性粒细胞 / 淋巴细胞比值与冠脉狭窄程度的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
98-101
栏目:
论著
出版日期:
2020-12-30

文章信息/Info

Title:
Correlation between the Degree of Coronary Stenosis and the Neutrophil/Lymphocyte Ratio in Patients with Coronary Artery Disease
文章编号:
1671-7414（2020）06-098-04
作者:
陈青文; 李丹丹
(中国人民解放军东部战区总医院检验科，南京 210002)
Author(s):
CHEN Qing-wen;  LI Dan-dan
(Department of Clinical Laboratory, Eastern Theater General Hospital of PLA, Nanjing 210002,China)
关键词:
冠心病; 中性粒细胞 / 淋巴细胞比值; 冠脉狭窄程度
分类号:
R541.4；R446.111
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.024
文献标志码:
A
摘要:
目的　分析冠心病（coronary artery disease，CAD）患者外周血中性粒细胞 / 淋巴细胞比值（neutrophil/lymphocyte ratio，NLR）与冠脉狭窄程度的相关性，探讨 NLR 的临床应用价值。方法　收集 2016 年 7 月～ 2018 年 9月东部战区总医院心血管内科收治的 278 例 CAD 患者和同期来院体检的 117 例健康对照者的临床资料、血细胞检测及血生化指标，根据病情将 CAD 患者分为稳定型冠心病（stable coronary artery disease，SCAD）和急性冠脉综合征（acute coronary syndrome，ACS）两组，同时根据冠状动脉造影结果又将 CAD 患者分为观察组、单支病变组、双支病变组和三支病变组，统计各组患者 Gensini 积分。比较各组间外周血 WBC，NLR 及 CRP 水平差异，并分析 NLR 与心肌肌钙蛋白 I （cTnI）水平和 Gensini 积分的相关性，ROC 曲线分析 NLR 对 CAD 病情的辅助诊断价值。结果　外周血WBC，NLR 及 CRP 在各组中差异有统计学意义 (χ 2 =29.962，31.045，F=17.656，均 P<0.05)，且 NLR 与 CAD 患者 cTnI水平和 Gensini 积分呈正相关 (r =0.381，P=0.000；r =0.217，P=0.000)；NLR 用于诊断 CAD,SCAD 及 ACS 患者的 ROC曲线下面积分别为0.720(95%CI: 0.671~0.770，P=0.000)，0.643(95%CI: 0.582~0.704，P=0.000)，0.835(95%CI: 0.787~0.884，P=0.000)。结论　NLR 水平可作为冠脉狭窄程度的辅助评估指标。

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更新日期/Last Update: 2020-12-20