[1]吕美玲,马婕群,陈海艳.乳腺癌患者血清长链非编码 RNA mir4435-2HG 表达水平与临床病理特征的相关性研究[J].现代检验医学杂志,2021,36(03):23-26.[doi:10.3969/j.issn.1671-7414.2021.03.006]
　L? Mei-ling,MA Jie-qun,CHEN Hai-yan.Correlation between Expression Level of Serum Long Non-codingRNA mir4435-2HG and Clinicopathological Characteristics inBreast Cancer Patients[J].Journal of Modern Laboratory Medicine,2021,36(03):23-26.[doi:10.3969/j.issn.1671-7414.2021.03.006]
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乳腺癌患者血清长链非编码 RNA mir4435-2HG 表达水平与临床病理特征的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
23-26
栏目:
论　著
出版日期:
2021-05-31

文章信息/Info

Title:
Correlation between Expression Level of Serum Long Non-codingRNA mir4435-2HG and Clinicopathological Characteristics inBreast Cancer Patients
文章编号:
1671-7414（2021）03-023-04
作者:
吕美玲; 马婕群; 陈海艳
(1. 长安大学医院内科，西安 710064；2. 陕西省肿瘤医院肿瘤内科，西安 710061；3. 西安国际医学中心医院肿瘤科，西安 710100）
Author(s):
L? Mei-ling1;  MA Jie-qun2;  CHEN Hai-yan3
(1.Department of Internal Medicine, Hospital of Chang’an University, Xi’an 710064, China；2.Medical Oncology,Shaanxi Provincial Cancer Hospital, Xi ’an 710061, China；3.Department of Oncology, Xi ’an International MedicalCenter Hospital, Xi ’an 710100, China)
关键词:
乳腺癌; 长链非编码 RNA ; 病理特征; 生物学标志物
分类号:
R737.9；R730.43
DOI:
10.3969/j.issn.1671-7414.2021.03.006
文献标志码:
A
摘要:
目的　探究乳腺癌 (breast cancer, BC) 患者血清长链非编码 RNA (long non-coding RNA, lnc RNA) mir4435-2HG表达水平与临床病理特征的相关性。方法　选择 2016 年 8 月 ~2017 年 7 月长安大学医院收治的 52 例 BC 患者为 BC组，选择同期 49 例乳腺良性疾病患者为乳腺良性疾病组，另随机纳入同期 45 例体检健康的志愿者为健康对照组。采用实时荧光定量 PCR(Quantitative real-time PCR, qRT-PCR) 检测血清 lnc RNA mir4435-2HG，通过比较各组血清中 lnc RNAmir4435-2HG 相对表达量的差异，分析 lnc RNA mir4435-2HG 与患者各临床病理特征的关系。lnc RNA mir4435-2HG 的诊断价值分析采用 ROC 曲线。结果　血清 lnc RNA mir4435-2HG 在 BC 组 [2.04(1.41，3.96)]，乳腺良性疾病组 [1.21(1.00，1.39)] 和健康对照组 [0.99(0.84，1.15)] 的相对表达量比较差异具有统计学意义 (H=28.73，P=0.00)，BC 组血清 lnc RNAmir4435-2HG 的相对表达量高于乳腺良性疾病组 (U=89.23，P=0.01) 和健康对照组 (U=91.46，P=0.02)。BC 患者血清 lncRNA mir4435-2HG 与年龄和肿瘤大小无显著相关性 (U=115.41，155.02，均 P ＞ 0.05)，而与淋巴结转移、TNM 分期、ER，PR 和 Her2 有显著相关性 (U=87.32，90.51，102.74，98.73，91.50，均 P ＜ 0.05)。lnc RNA mir4435-2HG 诊断 BC的最佳截断值为 0.69，该截断值对应的灵敏度和特异度分别为 80.25% 和 70.91%。结论 lnc RNA mir4435-2HG 在 BC血清中高表达，可作为 BC 的潜在生物学标志物。

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备注/Memo

备注/Memo:
作者简介：吕美玲（1988-），女，硕士，主治医师，研究方向：肿瘤的临床诊疗，E-mail:742242849@qq.com。
通讯作者：陈海艳（1987-），女，硕士，主治医师，研究方向：肿瘤的临床诊疗，E-mail:404704950@qq.com。
更新日期/Last Update: 1900-01-01