[1]赵白信,于慧娟,焦方杰,等.经阴道彩色多普勒超声联合血清 miR-130a,miR-425-5p 水平检测对宫颈癌的诊断效能分析[J].现代检验医学杂志,2021,36(03):43-47.[doi:10.3969/j.issn.1671-7414.2021.03.010]
 ZHAO Bai-xin,YU Hui-juan,JIAO Fang-jie,et al.Analysis of Diagnostic Efficacy of Transvaginal Color Doppler UltrasoundCombined with Serum miR-130a and miR-425-5p Levels in Cervical Cancer[J].Journal of Modern Laboratory Medicine,2021,36(03):43-47.[doi:10.3969/j.issn.1671-7414.2021.03.010]
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经阴道彩色多普勒超声联合血清 miR-130a,miR-425-5p 水平检测对宫颈癌的诊断效能分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
43-47
栏目:
论 著
出版日期:
2021-05-31

文章信息/Info

Title:
Analysis of Diagnostic Efficacy of Transvaginal Color Doppler UltrasoundCombined with Serum miR-130a and miR-425-5p Levels in Cervical Cancer
文章编号:
1671-7414(2021)03-043-05
作者:
赵白信于慧娟焦方杰
(郑州市第七人民医院功能科,郑州 450000)
Author(s):
ZHAO Bai-xin YU Hui-juan JIAO Fang-jie XING Li-li HUANG Lei YAO Hui-mei
(Department of Function, the Seventh People’s Hospital of Zhengzhou City, Zhengzhou 450000, China)
关键词:
宫颈癌阴道彩色多普勒超声微小核糖核酸 -130a微小核糖核酸 425-5p
分类号:
R737.33;R730.43
DOI:
10.3969/j.issn.1671-7414.2021.03.010
文献标志码:
A
摘要:
目的 分析经阴道彩色多普勒超声联合血清 miR-130a,miR-425-5p 水平检测对宫颈癌的诊断效能。方法 选取 2017 年 1 月~ 2019 年 1 月在郑州市第七人民医院诊治的宫颈癌患者 58 例和宫颈炎及宫颈上皮瘤变者 77 例分别为癌症组和疾病组,60 例同期来院体检结果正常的健康女性为对照组。对三组实施经阴道彩色多普勒超声检查,并使用实时荧光定量 PCR 法检测血清 miR-130a,miR-425-5p 水平。分析经阴道彩色多普勒超声联合血清 miR-130a,miR-425-5p表达对宫颈癌的诊断效能。结果 癌症组、疾病组和对照组的收缩期血流速度(peak systolic velocity,PSV)(12.01±2.85,9.53±1.98 和 8.52±1.23cm/s)依次降低 , 阻力指数(resistive index,RI)(0.42±0.10,0.58±0.12 和 0.66±0.14)依次升高,差异有统计学意义(F=43.178,60.098,均 P < 0.001);癌症组、疾病组和对照组的血清 miR-130a(0.092±0.030,0.045±0.012 和 0.030±0.008),miR-425-5p(0.733±0.203,0.365±0.098 和 0.205±0.048)表达水平依次升高,差异有统计学意义(F=181.070,259.304,P < 0.001)。受试者工作特征曲线(receiver operating characteristic curve,ROC)显示经阴道多普勒超声诊断宫颈癌的敏感度、特异度、准确度、曲线下面积(area under curve,AUC)分别为77.59%,87.01%,82.96% 和 0.889;血清 miR-130a 分别为 79.31%,80.52%,80.00% 和 0.820;血清 miR-425-5p 分别为 74.14%,77.92%,76.30% 和 0.785;联合诊断分别为 74.14%,90.91%,83.70% 和 0.932,三者联合检测的 AUC 大于单独检测(P < 0.05)。结论 阴道彩色多普勒超声联合血清 miR-130a 和 miR-425-5p 的表达对宫颈癌具有较高的诊断效能。

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备注/Memo

备注/Memo:
作者简介:赵白信(1981-),女,本科,主治医师,研究方向:成人腹部、浅表器官、小儿心脏及胎儿产前超声诊断。
通讯作者:姚辉梅。
更新日期/Last Update: 1900-01-01