[1]尹良琼,余艾霞.降钙素原、胱抑素C联合检测对脓毒症患儿28天死亡率的预测价值研究[J].现代检验医学杂志,2017,32(02):153-156，159.[doi:10.3969/j.issn.1671-7414.2017.02.043]
　YIN Liang-qiong,Y Ai-xia.Predictive Value of the Combined Detection of Procalcitonin and Cystatin C in Children with Sepsis 28 Days Mortality[J].Journal of Modern Laboratory Medicine,2017,32(02):153-156，159.[doi:10.3969/j.issn.1671-7414.2017.02.043]
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降钙素原、胱抑素C联合检测对脓毒症患儿28天死亡率的预测价值研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
153-156，159
栏目:
检验与临床
出版日期:
2017-03-25

文章信息/Info

Title:
Predictive Value of the Combined Detection of Procalcitonin and Cystatin C in Children with Sepsis 28 Days Mortality
文章编号:
1671-7414(2017)02-153-05
作者:
尹良琼; 余艾霞
鄂州市中心医院，湖北鄂州 43600 0
Author(s):
YIN Liang-qiong; Y Ai-xia
Ezhou Cent ral Hospital，Hubei Ezhou 436000，China
关键词:
脓毒血症; 降钙素原; 胱抑素C; 死亡率
分类号:
R515；R446.112
DOI:
10.3969/j.issn.1671-7414.2017.02.043
文献标志码:
A
摘要:
目的 探讨降钙素原(procalcitonin，PCT)、胱抑素C(Cyst atin C，Cys-C)联合检测对评估脓毒血症患儿的预后价值。方法 〖HT5”K 〗收集鄂州市中心医院儿科收住确诊为脓毒症患儿68例，记录患者一般情况，小儿危重病 例评分(PCIS)。抽取静脉血，微粒子酶免疫分析法检测所有患者血清中PCT及Cys-C的表达 情况。随访28天，记录患儿生存情况。Pearson相关分析检验PCT，Cys-C与PCIS的相关性； 多因素Logistic回归分析PCT，Cys-C以及其他危险因素与脓毒症患儿28天死亡率的相关性 。ROC曲线分析比较PCT，Cys-C在脓毒症患儿预后评估中的价值，最后进一步用统计学方法 分析PCT，Cys-C二者联合对脓毒症患儿预后的评估价值。结果 随 访28天后，①68例脓毒症患儿中28例死亡，占整体人数的41.18%。②死亡组患儿血清PCT 浓度为67.2±20.6 ng/ml，明显高于生存组44.5±13.0 ng/ml(t=－5.57，P<0 .01)；死亡组患儿血清Cys-C浓度为78.8±21.4 mg/ml，明显高于生存组64.2±16. 9(t=－3.14，P<0.01)。③Pearson相关分析结果显示外周血PCT和Cys-C表达与PCI S呈负相关(r=－0.578，－0.761，P均<0.05)。④多因素回归结果显示，PCT和Cys- C均为脓毒症患儿死亡的独立危险因素(P<0.001)。⑤ROC曲线分析结果显示PCT和Cys- C曲线下面积(AUC)分别为0.866(95%CI=0.749～0.93)，0.87(95%CI=0.77～0.94)。PC T，Cys-C二者联合检测AUC值为0.89(95%CI=0.82～0.95)，优于单一检测PCT及Cys-C (均P<0.05)。结论 PCT与Cys-C联合检测在评估脓毒症患儿死 亡率时具有良好的预测价值。
Abstract:
Objective To investigate the prediction value o f procalcitonin and Cystatin C in the evaluation of patients with sepsis 28 day mortality．Method A total of 106 patients with sepsis in Ezhou central hospital.The expressions of PTC and Cys-C in the serums of the p atients were measured on the first day of the hospitalization by microparticle e nzyme immunoassay．Pearson correlation analysis was performed to test the correl ation of PTC and Cys-C with PCIS．Logistic regression models were used to exami ne the risk factors of patients’ death．The AUC curve was used to test the valu e of PTC and Cys-C in prognosis of patients with sepsis．Result After follow-up 28 days：①41.18% patients (n=21) diedat the end o f the follow up.②In the death group，the PCT concentration was 67.2±20.6ng/ ml，significantly higher than the survival group (44.5±13 ng/ml，t=－5. 57，P<0.01)；the Cys-C was 78.8±21.4 mg/ml，significantly higher than th e survival group (64.2±16.9，t=－3.14，P<0.01)．③Pearson correlation a nalysis showed that the expression of PCT and Cys-C in peripheral blood was neg atively correlated with PCIS　(r=－0.578，－0.761，all P<0.05)．④Mul tivariate logistic regression showed PTC and Cys-C were the independent risk fa ctors for prognosis of patients with sepsis (P<0.05)．⑤ROC analysis showed the AUC value of PTC and Cys-C were 0.866　(95%CI=0.749～0.93)，0.87　(95%C I=0.77～0.94)respectly．The AUC value of (PTC & Cys-C) was 0.89　(95%CI，0. 82～0.95)，which wassignificantly increased compared with PTC or Cys-C　(both P<0.05)．Conclusion The combined detection of PCT an d Cys-C has good predictive value in the evaluation of mortality in children wi th sepsis．

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备注/Memo

备注/Memo:

作者简介:尹良琼(1973-)，〖HT6，7〗女，硕士，主管技师，研究方 向：主要从事临床常见疾病检验分析的研究，Tel：18062306867，E-mail：EZyinliangqio ng@yeah.net。
通讯作者:余艾霞，E-mail：wylteam@163.com。
更新日期/Last Update: 2017-04-10