[1]韩　响,洪嘉蕴,马　钰,等.儿童浆细胞瘤并发EBV感染病例的临床病理学特征和相关分析[J].现代检验医学杂志,2022,37(02):28-32.[doi:10.3969/j.issn.1671-7414.2022.02.006]
　HAN Xiang,HONG Jia-yun,MA Yu,et al.Clinicopathological Analysis of Children Plasmacytoma Complicated with EBV Infection[J].Journal of Modern Laboratory Medicine,2022,37(02):28-32.[doi:10.3969/j.issn.1671-7414.2022.02.006]
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儿童浆细胞瘤并发EBV感染病例的临床病理学特征和相关分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年02期
页码:
28-32
栏目:
论　著
出版日期:
2022-03-15

文章信息/Info

Title:
Clinicopathological Analysis of Children Plasmacytoma Complicated with EBV Infection
文章编号:
1671-7414（2022）02-028-05
作者:
韩　响1; 洪嘉蕴1; 马　钰2; 李文生2
（1. 西安医学院，西安 710068；2. 陕西省人民医院病理科，西安 710068）
Author(s):
HAN Xiang1;  HONG Jia-yun1;  MA Yu2; LI Wen-sheng2
（1.Xi’an Medical College, Xi’an 710068 China；2.Department of Pathology, Shaanxi Provincial People’s Hospital, Xi’an 710068, China）
关键词:
浆细胞瘤; 儿童; EB病毒
分类号:
R733.73；R730.43
DOI:
10.3969/j.issn.1671-7414.2022.02.006
文献标志码:
A
摘要:
目的　探讨儿童浆细胞瘤并发EB 病毒（Epstein-Barr virus，EBV）感染病例的临床病理学特征、诊断及鉴别诊断。方法　收集陕西省人民医院病理科2020 年11 月诊断的儿童浆细胞瘤1 例患者的临床资料，观察其组织形态学特征，通过免疫组织化学（immunohistochemistry，IHC）染色、原位杂交（in situ hybridization，ISH）技术，分析其免疫表型及分子特征，并复习相关文献。结果　患者女性，11 岁，病变位于左额颅骨，肿瘤最大径3.5cm。镜下观察分化较成熟浆细胞弥漫性浸润，免疫组织化学瘤细胞表达CD38，CD138，MUM-1，bob-1，CD79a，LAMBDA 及KAPPA 具有轻链限制性和EB 病毒编码的RNA（EBER）原位杂交检测EBER 阳性。病理诊断：儿童浆细胞瘤并发EBV 感染。结论　儿童浆细胞瘤并发EBV 感染极为罕见，应提高对此病临床病理特征的认识，避免误诊。
Abstract:
Objective　To investigate the clinicopathological characteristics, diagnosis and differential diagnosis of children plasmacytoma complicated with Epstein-Barr virus(EBV) infection. Methods　The clinical information of one case children plasmacytoma complicated with EBV infection diagnosed in the Department of Pathology, Shaanxi Provincial People’s Hospitall on November 2020 was retrieved. The histomorphological characteristics were observed. The immunophenotype and molecular characteristics were analyzed by immunohistochemistry(IHC) staining and in situ hybridization(ISH), and the relevant literature was revewed. Results　A female patient, 11 years old, had the lesion on the left frontal skull and the tumor had a maximum diameter of 3.5 cm.Histologic examination showed that diffuse infiltration by well- differentiated tumor cells. IHC showed that the tumor cells were positive for CD38, CD138, MUM-1, bob-1, CD79a, LAMBDA and KAPPA with light chain restricted, and EBV encoded RNA(EBER) was positive by in situ hybridization. Conclusion　Plasmacytoma complicated with EBV infection in children is extremely rare. The understanding of the clinicopathological features of the disease should be improved to avoid misdiagnosis.

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备注/Memo

备注/Memo:
基金项目：陕西省人民医院领军人才项目（2021LJ-12）; 陕西省重点研发计划项目（2019SF-089)。
作者简介：韩响（1994-），女，在读硕士，研究方向：肿瘤病理，E-mail：793490869@qq.com。
通信作者：李文生（1968-），男，博士后，主任医师，研究方向：淋巴造血肿瘤病理，E-mail：liwensheng263@sohu.com。
更新日期/Last Update: 1900-01-01