[1]李 垚,杨 平.早发冠心病触珠蛋白水平及其在免疫调节中的作用研究[J].现代检验医学杂志,2015,30(01):98-100.[doi:10.3969/j.issn.1671-7414.2015.01.027]
　LI Yao,YANG Ping.Role of Haptoglobin in the Immunomodulatory in Patients with Premature Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2015,30(01):98-100.[doi:10.3969/j.issn.1671-7414.2015.01.027]
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早发冠心病触珠蛋白水平及其在免疫调节中的作用研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
98-100
栏目:
论著
出版日期:
2015-01-30

文章信息/Info

Title:
Role of Haptoglobin in the Immunomodulatory in Patients with Premature Coronary Heart Disease
文章编号:
1671-7414(2015)01-098-03
作者:
李 垚; 杨 平
宝鸡市人民医院心内科,陕西宝鸡721000
Author(s):
LI Yao; YANG Ping
Department of Cardiology,Baoji People's Hospital,Shaanxi Baoji 721000,China
关键词:
冠心病;  触珠蛋白;  高敏C反应蛋白;  白介素-6
分类号:
R541.4; R392.11
DOI:
10.3969/j.issn.1671-7414.2015.01.027
文献标志码:
A
摘要:
目的 探讨触珠蛋白(haptoglobin,HP)在早发冠心病(coronary heart disease,CHD)免疫调节中的作用。方法 分析2012年1月～2014年1月在宝鸡市人民医院接受治疗的60例早发冠心病患者的临床资料(观察组),并纳入同期健康体检者40例作为对照组。 比较两组患者一般资料、血清Hp、高敏C反应蛋白(hs-CRP)和白介素-6(IL-6)水平,并分析相关性。结果 两组受试者一般资料比较,吸烟史观察组明显高于对照组,差异有统计学意义(27/33 vs 9/31,χ2=3.324,P<0.05),性别、年龄、体质指数、高血压、糖尿病等差异均无统计学意义(P>0.05)。观察组Hp、hs-CRP及IL-6水平均明显高于对照组,差异有统计学意义(97.76±23.08 mg/L vs 65.81±19.42 mg/L,10.43±3.81 mg/L vs 3.05±0.94 mg/L,16.43±4.59 pg/L vs 4.62±1.83 pg/L,P<0.001)。相关性分析显示,观察组Hp与hs-CRP(r=0.518,P<0.001)及IL-6(r=0.291,P=0.024)均呈现正相关。结论 冠心病患者血浆Hp水平明显升高,提示Hp在冠心病的发生发展中起一定的作用。
Abstract:
bjective To analyse the role of haptoglobin inthe immunomodulatory in patients with premature coronary heart disease.Methods Clinical data of 60 premature coronary heart disease patients and 40 healthy people was analysed.The general information and serume haptoglobin,hs-CRP and IL-6 were compared.Results Therewere no statistically difference between the two groups of the general information such as sex,years,BMI,hypertension and diabetes(P>0.05),excepts thesmoking history(27/33 vs 9/31,χ2=3.324,P<0.05).Hp,hs-CRP and IL-6 levels in the observer group were significantly higher than the control group,the difference was statistically significant(97.76±23.08 mg/L vs 65.81±19.42 mg/L,10.43±3.81 mg/L vs 3.05±0.94 mg/L,16.43±4.59 pg/L vs 4.62±1.83 pg/L,P<0.001).Correlation analysis showed that in the observer group Hp and hs-CRP showed a significant positive correlation(r=0.518,P<0.001),and the same results was found between IL-6 and Hp(r= 0.291,P=0.024).Conclusion Haptoglobin level was significantly increased in patients with coronary heart disease,which suggested that haptoglobin played a role in the development of coronary heart disease,and its level was correlated with IL-6.

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备注/Memo

备注/Memo:

作者简介:李 垚(1982-),本科,主治医师,研究方向:冠心病,Tel:15191961892,E-mail:wangliankai es@163.com。
更新日期/Last Update: 2015-01-30