[1]马钧,金一,王煜芳,等.尿胱抑素C在2型糖尿病肾病肾小管损伤早期诊断中的价值[J].现代检验医学杂志,2016,31(06):124-126，129.[doi:10.3969/j.issn.1671-7414.2016.06.036]
　MA Jun,JIN Yi,WANG Yu-fang,et al.Diagnosis Value of Urinary Cystatin C in Type 2 Diabetic Nephropathy Renal Tubular Injury[J].Journal of Modern Laboratory Medicine,2016,31(06):124-126，129.[doi:10.3969/j.issn.1671-7414.2016.06.036]
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尿胱抑素C在2型糖尿病肾病肾小管损伤早期诊断中的价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年06期
页码:
124-126，129
栏目:
研究简报·实验技术
出版日期:
2016-12-20

文章信息/Info

Title:
Diagnosis Value of Urinary Cystatin C in Type 2 Diabetic Nephropathy Renal Tubular Injury
作者:
马钧; 金一; 王煜芳; 许华英; 沙敏
南京医科大学附属苏州市立医院本部检验科,江苏苏州 215002
Author(s):
MA Jun; JIN Yi; WANG Yu-fang; XU Hua-ying; SHA Min
Department of Clinical Laboratory,Suzhou Municipal Hospital Affiliated to Nanjing Medical University,Jiangsu Suzhou 215002,China
关键词:
尿胱抑素C;  糖尿病肾病;  肾小管损伤
分类号:
R587.2; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.06.036
文献标志码:
A
摘要:
目的 探讨尿胱抑素C(Cys C)在2型糖尿病肾病(DN)肾小管损伤早期诊断中的价值。方法 2型糖尿病(T2DM)确诊病例72例,并按1989年 Mogensen提出的方法,根据尿清蛋白排泄率(UAER)分为三组:T2DM正常清蛋白尿组(UAER<30 mg/24h)26例,T2DM微量清蛋白尿组(UAER 30～300 mg/24h)28例,T2DM大量清蛋白尿组(UAER>300 mg/24h)18例,同时测定尿Cys C,α1微球蛋白(α1MU)和β2微球蛋白(β2MU)进行比较。结果 T2DM组尿Cys C为0.106±0.076 mg/L,明显高于对照组0.032±0.013 mg/L(t值为27.8,P=0.000); T2DM正常清蛋白尿组与对照组比较,尿Cys C与β2MU,差异均有统计学意义(P<0.05),而α1MU,差异无统计学意义(P>0.05); T2DM患者尿Cys C与α1MU,β2MU的相关性分析,尿Cys C与α1MU呈现明显的正相关(r=0.88,P=0.000),与β2MU也呈明显正相关(r=0.92,P=0.000); 以UAER>30 mg/24h为截点作T2DM患者尿Cys C与α1MU,β2MU的ROC曲线,其曲线下分布面积(AUC)分别为0.911,0.806,0.899,经比较尿Cys C与α1MU的AUCROC的差异具有统计学意义(P<0.05),尿Cys C与β2MU的AUCROC差异无统计学意义(P>0.05)。结论 尿Cys C的灵敏度和特异度与β2MU相当,要优于α1MU,且干扰因素少,是一种诊断DN早期肾小管损伤的敏感指标。
Abstract:
Objective To study the diagnosis value of urinary cystatin C(Cys C)in type 2 diabetic nephropathy(DN)renal tubular injury.Methods 72 cases of type 2 diabetes mellitus(T2DM)weredivided into three groups using urinary albumin excretion rate(UAER)accordingto the method proposed by Mogensen in 1989,T2DM normal albumin urine group(UAER<30 mg/24h)26 cases,T2DM Microalbuminuria urine group(UAER30～300 mg/24h)28cases,T2DM Macroalbuminuria urine group(UAER>300 mg/24h)18 cases,urinary Cys C,α1MU and β2MU were compared.Results T2DM urinaryCys C was 0.106±0.076 mg/L,significantly higher than the control group of 0.032±0.013 mg/L(t=27.8,P=0.000).Urinary Cys C and β2MU(P<0.05)both,while the α1MU P>0.05 in T2DM group compared with the controlgroup.Urinary Cys C and α1MU showed a significant positive correlation(r=0.88,P=0.000),and β2MU also showed a significant positive correlation withUrinary Cys C in T2DM patients correlation analysis(r=0.92,P=0.000).Using UAER>30 mg/24h as cut-off points made urinary Cys C,α1MU,β2MU ROC curve in T2DM patients,the area under the curve(AUC)were 0.911,0.806,0.899 respectively,urinary Cys C and α1MU has the statistically significant(P<0.05)and no difference between urinary Cys C with β2MU(P>0.05)in AUCROC.Conclusion The sensitivity and specificity of urinary Cys C was comparable to β2MU,which was better than α1MU.It is a sensitive indicator of early renal tubular injury in DN.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:马 钧(1974-),男,本科,副主任技师,研究方向:2型糖尿病肾病、妊娠期糖尿病等,Tel:18061995028,E-mail:martell 74@163.com。
更新日期/Last Update: 2016-12-20