[1]樊　华,弥　鹏,杨　波,等.肺癌患者外周血血小板参数检测分析及临床意义[J].现代检验医学杂志,2019,34(06):97-100.[doi:10.3969 ／ j.issn.1671-7414.2019.06.024]
　FAN Hua,MI Peng,YANG Bo,et al.Analysis and Clinical Value of Peripheral Platelet Parameters in Lung Cancer Patients[J].Journal of Modern Laboratory Medicine,2019,34(06):97-100.[doi:10.3969 ／ j.issn.1671-7414.2019.06.024]
点击复制

肺癌患者外周血血小板参数检测分析及临床意义()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年06期
页码:
97-100
栏目:
论著
出版日期:
2019-12-30

文章信息/Info

Title:
Analysis and Clinical Value of Peripheral Platelet Parameters in Lung Cancer Patients
文章编号:
1671-7414（2019）06-097-04
作者:
樊　华1; 弥　鹏2; 杨　波1; 陈　葳1
（1. 西安交通大学第一附属医院检验科，陕西西安　710061; 2. 陕西省人民医院检验科，陕西西安　710068）
Author(s):
FAN Hua1;  MI Peng2;  YANG Bo1;  CHEN Wei1
（1.Department of Clinical Laboratory, the First Affiliated Hospital of Xi ’an Jiaotong University, Xi ’an 710061, China; 2 .Department of Clinical Laboratory, Shaanxi Provincial People’s Hospital, Xi ’an 710068, China）
关键词:
血小板参数; 肺癌;  ROC 曲线
分类号:
R734.2；R730.43
DOI:
10.3969 ／ j.issn.1671-7414.2019.06.024
文献标志码:
A
摘要:
目的　分析外周血血小板参数检测在肺癌诊断中的价值及临床意义。方法　收集西安交通大学第一附属医院 2018 年8 月~2019 年4 月初次确诊的145 例肺癌患者及138 例同期体检合格者的血小板计数（PLT）、平均血小板体积 （MPV）、降钙素原（PCT）和血小板分布宽度（PDW）四项血小板参数结果，应用统计软件SPSS18 对收集的数据进 行统计分析。结果　PLT， MPV，PCT，PDW 在肺癌组的范围分别为(113~547)×109/L，8.10~14.60fl，11%~50%，和 8.8%~19%；在对照组的范围分别为(108~381)×109/L，7.40~13.20fl，11%~28% 和9.20%~17.30%。经秩和检验分析，差 异均有统计学意义（Z= ?5.288，?7.006，?8.590，?6.655，均P <0.05）。在肺小细胞癌、肺鳞癌、肺腺癌中比较，差异 无统计学意义（Chi-sq =0.909，4.902，2.782，0.790，均P >0.05）。四项血小板参数各单项检测在肺癌诊断中的ROC 曲线下面积AUC 为0.681~0.795，约登指数为0.30~0.47；各项联合检测的AUC 为0.777~0.898，约登指数为0.375~0.525。 结论　血小板参数检测在肺癌诊断中有辅助诊断意义，无鉴别分型意义。在肺癌辅助诊断中联合检测优于单项检测。
Abstract:
Objective　To analyze the performance and clinical value of peripheral platelet parameters in the diagnosis of lung cancer. Methods　The platelet parameters of 145 patients with lung cancer and 138 healthy subjects who passed physical examination during the same period were collected from the First Affiliated Hospital of Xi'an Jiaotong University from August 2018 to April 2019. The four platelet parameters included PLT, MPV , PCT and PDW. Statistical software SPSS18 was used for analysis of the collected data .Results The scope of PLT, MPV , PCT and PDW in perripheral blood of lung cancer patients were (113~547)×109/L, 9.80~14.60 fl, 11%~50% and 8.8%~19% respectively, but in healthy subjects were（108~381）×109/L, 7.40~13.20fl, 11%~28% and 9.20%~17.30% respectively. Analysis by rank sum test, the difference was statistically significant (Z=?5.288, ?7.006, ?8.590, ?6.655, all P <0.05).There was no statistically significant difference among the small cell carcinoma of lung, squamous cell carcinoma of lung and adenocarcinoma of lung (Chi-sq=0.909, 4.902, 2.782, 0.790, all P >0.05). The area under the ROC curve (AUC) of the four platelet parameters in the diagnosis of lung cancer range from 0.681 to 0.795, and the youden index was from 0.30 to 0.47. The AUC of the combined detections range from 0.777 to 0.898,the youden index was from 0.375 to 0.525. Conclusion The four parameters of platelets are helpful in the diagnosis of lung cancer, but they have no significance in differential classification of lung cancer.Combined detection is better than single detection in the auxiliary diagnosis of lung cancer.

参考文献/References:

[1]　买志福, 杨波, 蔡小玲, 等. 血小板与癌症的研究进 展[J]. 现代检验医学杂志,2018,33(5):161-164. MAI Zhifu, YANG Bo, CAI Xiaoling, et al. Research progress on the interaction between platelets and cancer [J]. Journal of Modern Laboratory Medicine, 2018,33(5):161-164.
[2]　JIN Ke, LI Tong, VAN DAM H,et al.Molecular insights into tumour metastasis:tracing the dominant events [J]. Journal of Pathology,2017,241(5):567-577.
[3]　丁贤彬, 唐文革, 曾永胜, 等.2010~2017 年重庆市肺 癌发病和死亡趋势变化[J]. 中国肿瘤,2019,28(8):577- 582. DING Xianbin,TANG Wenge, ZENG Yongsheng, et al. Trend of the incidence and mortality of lung cancer in Chongqing municipality from 2010 to 2017 [J]. China Cancer, 2019, 28(8):577-582.
[4]　鲍萍萍, 吴春晓, 张敏璐, 等.2015 年上海市恶性肿 瘤流行特征分析[J]. 中国癌症杂志,2019,29(2):81-99. BAO Pingping, WU Chunxiao, ZHANG Minlu ,et al. Report of cancer epidemiology in Shanghai, 2015 [J]. China Oncology, 2019,29(2):81-99.
[5]　DAVIS A N, AFSHAR-KHARGHAN V, SOOD A K. Platelet effects on ovarian cancer[J]. Seminars in Oncology, 2014,41(3):378-384
[6]　孙旺远, 高蔚, 翁婷, 等. 肺癌患者血小板参数的临 床意义[J]. 中国校医,2017,31(5):365-367. SUN Wangyuan, GAO Wei, WENG Ting, et al. Clinical value of platelet parameters in patients with lung cancer [J]. Chinese Journal of School Doctor, 2017,31(5):365-367.
[7]　张永瑞, 白泽坤, 翟丽, 等. 肿瘤患者血小板参 数显示不全的原因分析[J]. 国际检验医学杂 志,2018,39(20):2531-2533,2537. ZHANG Yongrui, BAI Zekun, ZHAI Li, et al. Analysis of causes on incomplete displays of platelet parameters in patients with tumors[J]. International Journal of Laboratory Medicine, 2018,39(20):2531- 2533,2537.
[8]　王珊珊, 张立. 血小板参数在乳腺癌患者早期诊断 中的价值研究[J]. 现代肿瘤医学,2019,27(6):985- 987. WANG Sansan, ZHANG Li. The value of platelet parameters in early diagnosis of breast cancer [J].Journal of Modern Oncology, 2019,27(6):985-987.
[9]　李晶晶, 钟春生. 血小板与肿瘤相关性研究进展[J]. 现代肿瘤医学,2017,25(23):3896-3900. LI Jingjing, ZHONG Chunsheng. Research progress on the correlation of platelets and tumor [J]. Journal of Modern Oncology, 2017,25(23):3896-3900.
[10] 马斌荣.SPSS(PASW)17.0 在医学统计中的应用[M].5 版. 北京: 科学出版社,2015:207-208. MA Binrong. Application of SPSS (PASW) 17.0 in medical statistics [M]. 5th Edition. Beijing: Science Press,2015:207-208.

相似文献/References:

[1]马丽颜,梁 静,周建龙.腺瘤样结肠息肉易感基因(APC)及结直肠癌缺失基因(DCC)基因甲基化在肺癌早期诊断的意义[J].现代检验医学杂志,2016,31(01):17.[doi:10.3969/j.issn.1671-7414.2016.01.005]
　MA Li-yan,LIANG Jing,ZHOU Jian-long.Evaluation of the Combination of APC and DCC Gene Methylation in the Early Diagnosis of Lung Cancer[J].Journal of Modern Laboratory Medicine,2016,31(06):17.[doi:10.3969/j.issn.1671-7414.2016.01.005]
[2]彭 瑛,邓正华,温先勇.国内13种血清肿瘤标志物对肺癌诊断价值的Meta分析[J].现代检验医学杂志,2016,31(01):96.[doi:10.3969/j.issn.1671-7414.2016.01.028]
　PENG Ying,DENG Zheng-hua,WEN Xian-yong.Diagnostic Value of Thirteen Types of Serum Tumor Markers for Lung Cancer in China:A Meta-Analysis[J].Journal of Modern Laboratory Medicine,2016,31(06):96.[doi:10.3969/j.issn.1671-7414.2016.01.028]
[3]翟海军,朱晶.红细胞分布宽度对肺癌预后的临床分析[J].现代检验医学杂志,2015,30(06):147.[doi:10.3969/j.issn.1671-7414.2015.06.045]
　ZHAI Hai-jun,ZHU Jing.Clinical Analysis of Red Blood Cell Distribution Width on the Prognosis of Lung Cancer[J].Journal of Modern Laboratory Medicine,2015,30(06):147.[doi:10.3969/j.issn.1671-7414.2015.06.045]
[4]姜 波,王玉明,段 勇.肺癌组织中调控PUMA基因 的miRNA筛查和MiR-221表达差异研究[J].现代检验医学杂志,2015,30(01):15.[doi:10.3969/j.issn.1671-7414.2015.01.005]
　JIANG Bo,WANG Yu-ming,DUAN Yong.Study on the Differential Expression of miRNA Screening and MiR-221 Regulates Apoptosis by Targeting PUMA Gene in Lung Cancer[J].Journal of Modern Laboratory Medicine,2015,30(06):15.[doi:10.3969/j.issn.1671-7414.2015.01.005]
[5]赵车冬,闫玉珠,吴文婧,等.血清CEA,CYFRA21-1,NSE水平在肺癌诊断与分型中的应用价值[J].现代检验医学杂志,2016,31(06):59.[doi:10.3969/j.issn.1671-7414.2016.06.016]
　ZHAO Che-dong,YAN Yu-zhu,WU Wen-jing,et al.Application Value of Serum CEA,CYFRA21-1 and NSE Levels in the Diagnosis and Typing of Lung Cancer[J].Journal of Modern Laboratory Medicine,2016,31(06):59.[doi:10.3969/j.issn.1671-7414.2016.06.016]
[6]董 莉,张保平,冯新平,等.血浆HSP90α检测在肺癌诊断中的临床应用价值研究[J].现代检验医学杂志,2017,32(04):97.[doi:10.3969/j.issn.1671-7414.2017.04.027]
　DONG Li,ZHANG Bao-ping,FENG Xin-ping,et al.Plasma HSP90 Alpha Testing Clinical Application Value in the Diagnosis of Lung Cancer Researc[J].Journal of Modern Laboratory Medicine,2017,32(06):97.[doi:10.3969/j.issn.1671-7414.2017.04.027]
[7]张利祥,潘 静,赵 洁,等.痰液基细胞学检查与血清CYFRA21-1,CEA,NSE联合检测对肺癌的诊断价值[J].现代检验医学杂志,2019,34(03):99.[doi:10.3969/j.issn.1671-7414.2019.03.024]
　ZHANG Li-xiang,PAN Jing,ZHAO Jie,et al.Value of the Combined Determination of Sputum Liquid-Based Cytologyand Serum CYFRA21-1,CEA,NSE for the Diagnosis of Lung Cancer[J].Journal of Modern Laboratory Medicine,2019,34(06):99.[doi:10.3969/j.issn.1671-7414.2019.03.024]
[8]韩　光.外周血血小板参数对评估急性脑梗死患者生活能力改善的临床价值[J].现代检验医学杂志,2020,35(02):119.[doi:10.3969 ／ j.issn.1671-7414.2020.02.033]
　HAN Guang.Clinical Value of Platelet Parameters in Evaluating the Improvement of LifeAbility in Patients with Acute Cerebral Infarction[J].Journal of Modern Laboratory Medicine,2020,35(06):119.[doi:10.3969 ／ j.issn.1671-7414.2020.02.033]
[9]赵格a,高琼b,余宗涛a,等.肺癌患者血浆miR-3151 表达水平与临床病理特征的相关性研究[J].现代检验医学杂志,2020,35(05):28.[doi:10.3969/j.issn.1671-7414.2020.05.008]
　ZHAO Gea,GAO Qiongb,YU Zong-taoa,et al.Study on the Correlation between the Expression of miR-3151 in Plasma and Clinicopathological Features in Patients with Lung Cancer[J].Journal of Modern Laboratory Medicine,2020,35(06):28.[doi:10.3969/j.issn.1671-7414.2020.05.008]
[10]张曙晴,张骆军,李洪彬,等.血液小而密低密度脂蛋白胆固醇、抗凝血酶Ⅲ水平及血小板参数检测在2型糖尿病肾病中的应用价值研究[J].现代检验医学杂志,2021,36(02):70.[doi:doi:10.3969/j.issn.1671-7414.2021.02.017]
　ZHANG Shu-qing,ZHANG Luo-jun,LI Hong-bin,et al.Study on the Application Value of Detecting Small Dense Low-density Lipoprotein Cholesterol, Antithrombin-Ⅲ Levels and Platelet Parameter in the Patients with Type-2 Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2021,36(06):70.[doi:doi:10.3969/j.issn.1671-7414.2021.02.017]

备注/Memo

备注/Memo:
作者简介：樊华（1991-），女，硕士研究生，医学检验技师，专业：临床检验，E-mail:820430078@qq.com。 通讯作者：陈葳，女，主任检验医师，硕士博士生导师，主要研究方向：肿瘤分子诊断，E-mail:chenwei808@ xjtu. edu. Cn 收稿日期：2019-07-21
更新日期/Last Update: 2019-12-25