[1]牛智平,王娟,汪富涛,等.乳腺癌组织中lncRNA PVT1 的表达与患者临床特征及总体生存率的关系[J].现代检验医学杂志,2020,35(05):134-136.[doi:10.3969/j.issn.1671-7414.2020.05.035]
　NIU Zhi-ping,WANG Juan,WANG Fu-tao,et al.Relationship between the Expression of lncRNA PVT1 in Breast Cancer Tissues and the Clinical Characteristics and Overall Survival Rate of Patients[J].Journal of Modern Laboratory Medicine,2020,35(05):134-136.[doi:10.3969/j.issn.1671-7414.2020.05.035]
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乳腺癌组织中lncRNA PVT1 的表达与患者临床特征及总体生存率的关系()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年05期
页码:
134-136
栏目:
检验与临床
出版日期:
2020-11-01

文章信息/Info

Title:
Relationship between the Expression of lncRNA PVT1 in Breast Cancer Tissues and the Clinical Characteristics and Overall Survival Rate of Patients
文章编号:
1671-7414（2020）05-134-03
作者:
牛智平1; 王娟2; 汪富涛1; 成勇1; 舒俊伟1; 杜嘉源1
1. 安康市人民医院普外科，陕西安康 725000，2. 西安大兴医院妇产科 西安 710014
Author(s):
NIU Zhi-ping1;  WANG Juan2;  WANG Fu-tao1;  CHENG Yong1;  SHU Jun-wei1;  DU Jia-yuan1
1.Department of General Surgery, Ankang People’s Hospital, Shaanxi Ankang 725000,China; 2.Department of Obstetrics,Xi’an Daxing Hospital, Xi’an 710014,China
关键词:
乳腺癌; IncRNA PVT1; 临床特征; 总体生存率
分类号:
R737.9；R730.43
DOI:
10.3969/j.issn.1671-7414.2020.05.035
文献标志码:
A
摘要:
目的　探讨乳腺癌组织中lncRNA PVT1 的表达与患者临床特征及总体生存率的关系。方法　采用实时荧光 定量PCR 法检测乳腺癌组织及其相应癌旁正常组织中lncRNA PVT1 的相对表达量；分析lncRNA PVT1 表达水平与 乳腺癌患者临床特征与总体生存率间的关系。结果　lncRNA PVT1 在乳腺癌组织中的相对表达量显著高于癌旁正常 组织(0.007 5 vs 0.003)，其差异具有统计学意义(P=0.0186)。lncRNA PVT1 表达水平与乳腺癌患者的年龄(χ2=5.948， P=0.015)、临床分期(χ2=12.349，P=0.006)、淋巴结转移(χ2=20.942，P<0.001)、远端转移(χ2=5.330，P=0.021) 和 Her2(χ2=5.221，P=0.022) 显著相关。lncRNA PVT1 高表达组患者的总体生存率(overall survival, OS) 显著低于lncRNA PVT1 低表达组，差异具有统计学意义(P=0.036)。结论 　lncRNA PVT1 是一种可预测乳腺癌患者预后的有潜力的生物 学指标。
Abstract:
Objective　To investigate the relationship between the expression of lncRNA PVT1 in breast cancer tissues and the clinical characteristics and overall survival rate of patients. Methods　The relative expression of lncRNA PVT1 in breast cancer tissues and adjacent normal tissues was detected by quantitative real-time PCR. Analyzed the relationship between the expression level of lncRNA PVT1 and the clinical characteristics and overall survival rate of breast cancer patients. Results　The relative expression of lncRNA PVT1 in breast cancer tissues was significantly higher than that in adjacent normal tissues, and the difference was statistically significant (P=0.0186). The expression level of lncRNA PVT1 was significantly correlated with age (χ2=5.948, P=0.015), clinical stage (χ2=12.349, P=0.006), lymph node metastasis (χ2=20.942, P<0.001), distal metastasis (χ2=5.330, P=0.021), and Her2 (χ2=5.221, P=0.022) in breast cancer patients. Overall survival rate (OS) of patients with high expression of lncRNA PVT1 was significantly lower than that of patients with low expression of lncRNAPVT1,and the difference was statistically significant (P=0.036). Conclusion　LncRNA PVT1 is a potential biological indicator to predict the prognosis of breast cancer patients.

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备注/Memo

备注/Memo:
作者简介：牛智平(1970-)，女，本科，副主任医师，研究方向：乳腺、胃肠道疾病的防治，E-mail:anniuzhip@163.com。
通讯作者：汪富涛(1986-)，男，硕士，主治医师，研究方向：微创技术在普外科的应用，E-mail:wangfutao313@163.com。
更新日期/Last Update: 2020-10-30