[1]刘立民,刘雪香,邹　燕,等.长链非编码RNA调控CD4+T淋巴细胞增殖分化和在免疫性疾病中的最新研究进展[J].现代检验医学杂志,2021,36(06):200-204.[doi:10.3969/j.issn.1671-7414.2021.06.044]
　LIU Li-min,LIU Xue-xiang,ZOU Yan,et al.Roles of lncRNA in Regulating the Proliferation, Differentiation of CD4+T Lymphocytes and Immune Diseases[J].Journal of Modern Laboratory Medicine,2021,36(06):200-204.[doi:10.3969/j.issn.1671-7414.2021.06.044]
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长链非编码RNA调控CD4+T淋巴细胞增殖分化和在免疫性疾病中的最新研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年06期
页码:
200-204
栏目:
综述
出版日期:
2021-12-15

文章信息/Info

Title:
Roles of lncRNA in Regulating the Proliferation, Differentiation of CD4+T Lymphocytes and Immune Diseases
文章编号:
1671-7414（2021）06-200-05
作者:
刘立民; 刘雪香; 邹　燕; 等
（柳州市工人医院/广西医科大学第四附属医院医学检验科，广西柳州 545005）
Author(s):
LIU Li-min;  LIU Xue-xiang;  ZOU Yan;  et al
（Department of Medical Laboratory, Liuzhou Worker Hospital/Fourth Affiliated Hospital of Guangxi Medical University, Guangxi Liuzhou 545005,China）
关键词:
长链非编码RNA; CD4+T淋巴细胞; 免疫; 表观遗传
分类号:
Q756；R446.6
DOI:
10.3969/j.issn.1671-7414.2021.06.044
文献标志码:
A
摘要:
长链非编码RNA（long non-coding RNA，lncRNA）是长度大于200nt的非编码RNA，其作用机制涉及染色质重塑、DNA转录及转录后修饰、蛋白翻译及翻译后调节，与免疫性疾病关系密切。CD4+T淋巴细胞在适应性免疫反应中发挥重要调控作用，体内的CD4+T淋巴细胞亚群相互配合维持免疫平衡。CD4+T淋巴亚群的比例失调，可能导致免疫失衡，甚至引起免疫性疾病。该文主要阐述lncRNA及其在CD4+T淋巴细胞的增殖分化和免疫性疾病中的调控作用。
Abstract:
Long non-coding RNA (lncRNA) is a type of non-coding RNA with a length greater than 200nt. The mechanism playing by lncRNA involves chromatin remodeling, DNA transcription and post-transcriptional modification, protein translation and post-translational regulation, and it would be closely related to immune diseases. CD4+T lymphocytes play a key regulatory role in the adaptive immune response, whose subsets were interacted with each other to maintain immune balance. Disproportionate CD4+T lymphocytes subsets may cause immune imbalance or even immune diseases. In this article, summarize roles of lncRNA in regulating the proliferation, differentiation of CD4+T lymphocytes, and immune diseases.

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更新日期/Last Update: 1900-01-01