[1]闫海燕,杨云秀,杨云华,等.老年糖尿病肾病患者血清SP-D水平表达及其基因多态性与并发肺部感染的相关性研究[J].现代检验医学杂志,2021,36(04):21-24.[doi:10.3969/j.issn.1671-7414.2021.04.005]
 YAN Hai-yan,YANG Yun-xiu,YANG Yun-hua,et al.Research on the Relationship between Serum SP-D Level, Gene Olymorphismand Pulmonary Infection in Elderly Patients with Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2021,36(04):21-24.[doi:10.3969/j.issn.1671-7414.2021.04.005]
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老年糖尿病肾病患者血清SP-D水平表达及其基因多态性与并发肺部感染的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年04期
页码:
21-24
栏目:
论 著
出版日期:
2021-07-31

文章信息/Info

Title:
Research on the Relationship between Serum SP-D Level, Gene Olymorphismand Pulmonary Infection in Elderly Patients with Diabetic Nephropathy
文章编号:
1671-7414(2021)04-021-04
作者:
闫海燕1杨云秀2杨云华3宋晓伟1缑 剑1
(1. 咸阳市第一人民医院呼吸与危重症医学科 陕西咸阳 712000;2. 陕西唐华四棉医院呼吸科,西安 710038;3. 西安北车医院内科,西安 710085)
Author(s):
YAN Hai-yan1 YANG Yun-xiu2 YANG Yun-hua3 SONG Xiao-wei1 GOU Jian1
(1.Department of Respiratory and Critical Care Medicine, the First People’s Hospital of Xianyang City, ShaanxiXianyang712000,China;2.Department of Respiration,Shaanxi Tanghua Simian Hospital,Xi’an 710038,China;3.Department of Internal Medicine,Xi’an Beiche Hospital,Xi’an 710085,China)
关键词:
血清SP-D基因多态性糖尿病肾病肺部感染
分类号:
R587.2;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.04.005
文献标志码:
A
摘要:
目的 研究老年糖尿病肾病(diabetic nephropathy, DN) 患者血清表面活性蛋白D(surfactant protein D, SP-D) 水平表达及其基因多态性与并发肺部感染的相关性。方法 收集2018 年4 月~2020 年10 月咸阳市第一人民医院108 例老年DN 患者作为研究对象,根据是否伴有肺部感染,将患者分为感染组(n=26) 和对照组(n=82)。比较两组患者血清SP-D水平,检测SP-D 基因多态性分布。参照肺炎严重指数(pneumonia severity index, PSI),记录26 例肺部感染患者严重程度。分析血清SP-D 及其基因多态性与肺炎严重程度的关系。结果 ELISA 结果显示,与对照组血清SP-D(20.02±4.54 ng/L)比较,感染组血清SP-D(24.18±5.39 ng/L)显著升高(t=3.888, P<0.05)。感染组患者SP-D 基因型频率分布(TT 型4 例、CT 型7 例和CC 型15 例),与对照组(TT 型22 例、CT 型45 例和CC 型15 例) 比较,差异有统计学意义(χ2=15.310,P<0.05)。26 例肺部感染中轻度14 例、中度8 例和重度4 例。轻度组、中度组及重度组三组血清SP-D(17.24±3.77 ng/L,23.17±3.82 ng/L 及25.29±2.18 ng/L)水平比较,差异有统计学意义(F=11.325, P<0.05)。轻度组(TT 型3 例、CT 型5例和CC 型6 例)、中度组(TT 型1 例、CT 型2 例和CC 型5 例) 及重度组(TT 型0 例、CT 型0 例和CC 型4 例) 基因型分布比较,差异有统计学意义(χ2=4.288, P<0.05)。ROC 分析显示血清SP-D 判断DN 并发肺部感染的AUC 为0.779(SE=0.056,95%CI=0.669 ~ 0.890,P=0.000),敏感度和特异度分别为0.769 和0.598。结论  血清SP-D 有助于判断DN 并发肺部感染风险,CC 基因型患者较其他患者更易发生肺部感染。

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备注/Memo

备注/Memo:
作者简介:闫海燕(1983-),女,本科,主治医师,研究方向:呼吸重症,肺心病,肺部感染,E-mail:xianyyanhaiy@163.com。
通讯作者:宋晓伟(1987-),男,本科,研究方向:气道肿瘤,E-mail:415510359@qq.com。
更新日期/Last Update: 1900-01-01