[1]李　欢a,焦峰军a,苏颜平b.冠心病患者血清VASP和PAPP-A的表达水平与冠状动脉病变程度的相关性研究[J].现代检验医学杂志,2022,37(03):114-118.[doi:10.3969/j.issn.1671-7414.2022.03.024]
　LI Huana,JIAO Feng-juna,SU Yan-pingb.Study on the Correlation between the Expression Levels of Serum VASP and PAPP-A and the Severity of Coronary Artery Disease in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2022,37(03):114-118.[doi:10.3969/j.issn.1671-7414.2022.03.024]
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冠心病患者血清VASP和PAPP-A的表达水平与冠状动脉病变程度的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年03期
页码:
114-118
栏目:
论　著
出版日期:
2022-05-15

文章信息/Info

Title:
Study on the Correlation between the Expression Levels of Serum VASP and PAPP-A and the Severity of Coronary Artery Disease in Patients with Coronary Heart Disease
文章编号:
1671-7414（2022）03-114-05
作者:
李　欢a; 焦峰军a; 苏颜平b
（咸阳市第一人民医院a. 心内科；b. 药剂科，陕西咸阳 712000）
Author(s):
LI Huana; JIAO Feng-juna; SU Yan-pingb
（a.Department of Cardiology；b. Department of Pharmacy, the First People’s Hospital of Xianyang, Shaanxi Xianyang 712000, China）
关键词:
冠心病; 血管扩张刺激磷蛋白; 妊娠相关血浆蛋白A; 冠状动脉病变程度
分类号:
R541.4；R392.11
DOI:
10.3969/j.issn.1671-7414.2022.03.024
文献标志码:
A
摘要:
目的　研究冠心病（ coronary heart disease, CHD）患者血清血管扩张刺激磷蛋白（ vasodilator stimulated phosphoprotein，VASP)和妊娠相关血浆蛋白 A（pregnancy associated plasma protein-A，PAPP-A）的表达水平与病变程度的关系。方法　纳入 2017年 12月～ 2019年 12月期间咸阳市第一人民医院心内科收治的 200例 CHD患者作为研究对象，另纳入同期健康体检受试者 100例作为对照组，收集和检测所有受试者的一般资料、生化指标、血清 VASP和 PAPP-A的表达水平，以心脏外科与介入治疗狭窄冠状动脉研究（ SYNTAX）积分评价冠状动脉病变严重程度，对各指标进行 Pearson相关性分析和多元线性回归分析。结果　与对照组相比，研究组患者 FBG（6.55±1.33 mmol/L vs 4.92±0.83 mmol/L）, FINS（9.92±3.11 mIU/L vs 5.34±2.09 mIU/L）, HbA1c（8.50％±1.30％ vs 6.24％±0.26％）和 PAPP-A（17.93±5.14 mIU/L vs 10.43±2.96 mIU/L）的水平均显著升高，血清 VASP（290.77±57.88 ng/L vs 406.64±81.81 ng/L）的表达水平显著降低，差异均有统计学意义（ t=11.208～ 23.657，均 P＜ 0.001）。与 SAP组相比， UAP组和 AMI组患者血清 VASP（286.21±59.78 ng/L，225.85±54.09 ng/L vs 352.22±66.12ng/L）的表达水平较低 ,而 PAPP-A（18.01±4.52 mIU/L，26.71±5.59 mIU/L vs 13.23±3.14mIU/L）的表达水平均较高，差异有统计学意义（ F=69.261, 144.405，均 P＜ 0.001）；三组其余指标相比差异均无统计学意义（ F=0.210～ 2.363，均 P＞ 0.05）。SYNTAX积分 23～ 32分患者组的血清 VASP表达水平显著低于、而 PAPP-A显著高于 0～ 22分患者组； ≥ 33分患者组的血清 VASP表达水平显著低于、而 PAPP-A显著高于 0～ 22分以及 23～ 32分患者组，差异均有统计学意义（ F=67.098 ，139.984，均 P＜ 0.001）。 Pearson相关性分析显示，血清 VASP的表达水平与 SYNTAX积分呈负相关（ r=-0.208，P＜ 0.05），PAPP-A的表达水平与 SYNTAX积分呈正相关（ r=0.233，P＜ 0.05）。多元线性回归分析显示，血清 VASP（β=0.620，P=0.008）和 PAPP-A（β=0.884，P=0.005）的表达水平是 SYNTAX积分的独立影响因素。结论　CHD患者血清 VASP和 PAPP-A的表达水平与冠状动脉病变严重程度密切相关，可作为早期诊断和评估病情的重要生物学指标。
Abstract:
Objective　To investigate the correlation between expression levels of serum vasodilator stimulated phosphoprotein(VASP), pregnancy associated plasma protein-A(PAPP-A) and coronary lesion degree in patients with coronary heart disease(CHD). Methods　200 patients with CHD admitted to department of cardiology of the First People’s Hospital of Xianyang from December 2017 to December 2019 were accepted as research subjects,and 100 healthy subjects were collected as control group. The general information,biochemical indexes and expression levels of serum VASP and PAPP-A were collected and detected,and the coronary lesion degree was evaluated by SYNTAX. The correlation analysis and multiple linear regression analysis were conducted. Results　Compared with the control group, the levels of FBG（6.55±1.33 mmol/L vs 4.92±0.83mmol/L）,FINS（9.92±3.11 mIU/L vs 5.34±2.09 mIU/L）,HbA1c（8.50%±1.30% vs 6.24%±0.26%）and PAPP-A（17.93±5.14 mIU/L vs 10.43±2.96 mIU/L）in the study group were significantly increased, and the expression level of serum VASP(290.77±57.88 ng/L vs 406.64±81.81 ng/L） was significantly reduced, the differences were statistically significant(t=11.208 ~ 23.657, all P ＜ 0.001). Compared with the SAP group, the serum VASP（286.21±59.78 ng/L， 225.85±54.09 ng/L vs 352.22±66.12ng/L）was lower in UAP group and AMI group， while PAPP-A（18.01±4.52 mIU/L， 26.71±5.59 mIU/L vs 13.23±3.14mIU/L）the expression level of higher，the differences were statistically significant（F = 69.261, 144.405，均P ＜ 0.001）. There was no statistically significant difference among the remaining indicators of the three groups (F=0.210 ~ 2.363, all P ＞ 0.05). The expression levels of serum VASP of patients with 23 ~ 32 SYNTAX points were lower while PAPP-A were higher than patients with 0 ~ 22 SYNTAX points(F=67.098，139.984, all P ＜ 0.001).The expression levels of serum VASP of patients with ≥ 33 SYNTAX points were lower while PAPP-A were higher than patients with 0 ~ 22 and 23 ~ 32 SYNTAX points(P ＜ 0.05). The Pearson correlation analysis showed that the expression levels of serum VASP was negatively correlated with SYNTAX points(r =-0.208, P ＜ 0.001), the PAPP-A was positively correlated with SYNTAX points(r =0.233, P ＜ 0.001). Multiple linear regression analysis showed that the expression levels of serum VASP(β=0.620, P =0.008) and PAPP-A(β=0.884, P =0.005) were independently associated with SYNTAX points. Conclusion　The expression levels of serum VASP and PAPP-A in CHD patients were closely related to the severity of coronary artery disease, which could be important biological indicators for early diagnosis and evaluation of the pathogenetic condition of CHD.

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备注/Memo

备注/Memo:
作者简介：李欢（1983-），女，本科，副主任医师，研究方向：冠心病高血压方面，E-mail：li_huan1983@163.com。
通讯作者：苏颜平（1983-），女，本科，主管药师，研究方向：心血管内科用药，E-mail：494550645@qq.com。
更新日期/Last Update: 1900-01-01