[1]李苗苗,王玉红,刘 静.中国沈阳地区汉族冠心病患者CYP2C19基因多态性分布特征[J].现代检验医学杂志,2019,34(02):5-8.[doi:10.3969/j.issn.1671-7414.2019.02.002]
 LI Miao-miao,WANG Yu-hong,LIU jing.Distribution Characteristics of CYP2C19 Gene Polymorphismin Han Patients with Coronary Heart Disease in Shenyang,China[J].Journal of Modern Laboratory Medicine,2019,34(02):5-8.[doi:10.3969/j.issn.1671-7414.2019.02.002]
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中国沈阳地区汉族冠心病患者CYP2C19基因多态性分布特征()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年02期
页码:
5-8
栏目:
论著
出版日期:
2019-05-11

文章信息/Info

Title:
Distribution Characteristics of CYP2C19 Gene Polymorphismin Han Patients with Coronary Heart Disease in Shenyang,China
文章编号:
1671-7414(2019)02-005-05
作者:
李苗苗12王玉红1刘 静1
(1.北部战区总医院检验科,沈阳 110016; 2.大连医科大学研究生院,辽宁大连 116044)
Author(s):
LI Miao-miao12WANG Yu-hong1LIU jing1
(1.Department ofClinical Laboratory,Northern Theater Command General Hospital,Shenyang 110016,China; 2.Postgraduate College,Dalian Medical University,Liaoning Dalian116044,China)
关键词:
冠心病 CYP2C19 基因多态性 氯吡格雷代谢型
分类号:
R541.4; Q786
DOI:
10.3969/j.issn.1671-7414.2019.02.002
文献标志码:
A
摘要:
目的 探讨沈阳地区汉族冠心病(coronary heart disease,CHD)患者细胞色素P450 2C19(CYP2C19)基因多态性分布特征。方法 选取2016年1月~2018年1月于北部战区总医院(原沈阳军区总医院)入院接受治疗的冠心病患者2 748例,应用聚合酶链反应微阵列芯片杂交方法检测患者氯吡格雷代谢相关的CYP2C19基因型。根据性别、年龄因素对患者进行分组。采用四格表资料的χ2检验,R×C表资料的χ2检验比较各组间冠心病患者氯吡格雷代谢相关的CYP2C19*1,*2,*3基因型,*2,*3等位基因频率,及氯吡格雷代谢型的分布差异。结果 沈阳地区汉族冠心病患者CYP2C19*1/*1,CYP2C19*1/*2,CYP2C19*1/*3,CYP2C19*2/*2,CYP2C19*3/*3和CYP2C19*2/*3发生率分别为41.7%,39.3%,5.8%,9.8%,0.4%和3.0%; CYP2C19*2,CYP2C19*3等位基因频率分别为31.0%和4.8%; 氯吡格雷快代谢型(EM),氯吡格雷中间代谢型(IM),氯吡格雷慢代谢型(PM)发生率分别为41.7%,45.1%和13.2%。根据性别分组,患者CYP2C19*2,*3等位基因,氯吡格雷代谢型,CYP2C19的6种基因型在不同性别冠心病患者中的分布差异均无统计学意义(χ2=0.0329.205,P>0.05)。根据年龄分组<45岁,45~59岁,60~75岁,>75岁,患者CYP2C19*2,*3等位基因,CYP2C19的6种基因型在不同年龄冠心病患者中的分布差异均有统计学意义(χ2=17.71848.772,P≤0.001),氯吡格雷代谢型在不同年龄冠心病患者中的分布差异无统计学意义(χ2=4.442,P=0.617)。结论 沈阳地区汉族冠心病患者CYP2C19的6种基因型,CYP2C19*2,*3等位基因分布与沈阳地区汉族冠心病患者性别差异无关,与年龄分层密切相关。
Abstract:
Objective To investigate the distribution of Cytochrome P450 2C19(CYP2C19)gene polymorphism in Han patients with coronary heart disease(CHD)in Shenyang.Methods The genotype of CYP2C19 related to clopidogrel metabolic was detected by polymerase chain reactionmicroarray hybridization in 2 748 Han patients with coronary heart disease admitted to the Northern Theater Command General Hospital from January 2016 to January2018.The patients were grouped according to gender and age.Chi-square test was adopted to analysis the six differences of CYP2C19 genotypes,allele distribution of *2 and *3 in different age and sex CHD patients.Results The frequencies of CYP2C19*1/*1,CYP2C19*1/*2,CYP2C19*1/*3,CYP2C19*2/*2,CYP2C19*3/*3 and CYP2C19*2/*3 in Han patients with coronary heart disease in Shenyang,China were 41.7%,39.3%,5.8%,9.8%,0.4% and 3.0% respectively,the frequencies of CYP2C19*2 and CYP2C19*3 alleles were 31.0% and 4.8% respectively, extensive metabolizers(EM),intermediate metabolizers(IM)and poor metabolizers(PM)were 41.7%,45.1% and 13.2% respectively in Han patients withCHD in Shenyang.There was no statistically significant in the distribution ofCYP2C19*2 and *3 alleles,clopidogrel metabolic type and CYP2C19 genotypes amongpatients of different gender with coronary heart disease(χ2=0.032~9.205,all P>0.05).There was statistically significant in the distribution ofCYP2C19*2,*3 allele and CYP2C19 genotypes in patients of different ages with coronary heart disease was significantly different according to age groups <45y,45~59y,60~75y and >75y(χ2=17.718~48.772,all P≤0.001).There was no statistically significant in the distribution of patients and clopidogrel metabolic type in patients with coronary heart disease at different ages(χ2=4.442,P=0.617).Conclusion The distribution of CYP2C19 * 2,* 3 alleles and 6 genotypes of CYP2C19 in CHD patients of Han nationality in Shenyang areawas related with age,and not related with gender.

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备注/Memo

备注/Memo:
作者简介:李苗苗(1993-),女,在读硕士研究生,主要从事临床检验诊断方面研究,E-mail:819630044@qq.com。 通讯作者:刘 静(1986-),女,硕士,主管技师,主要研究方向:临床检验诊断,E-mail:jinjing8304@163.com。 收稿日期:2019-01-06 修回日期:2019-01-24 页码:8+13
更新日期/Last Update: 2019-04-30