[1]穆亚宏,王 瑞a,刘小玲b.血清α1-酸性糖蛋白水平对类风湿关节炎疗效的评价[J].现代检验医学杂志,2016,31(01):147-148.[doi:10.3969/j.issn.1671-7414.2016.01.043]
　MU Ya-hong,WANG Ruia,LIU Xiao-lingb.Evaluation of Serum Alpha 1-Acid Glycoprotein in Therapeutic Efficiency of Rheumatoid Arthritis[J].Journal of Modern Laboratory Medicine,2016,31(01):147-148.[doi:10.3969/j.issn.1671-7414.2016.01.043]
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血清α1-酸性糖蛋白水平对类风湿关节炎疗效的评价()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年01期
页码:
147-148
栏目:
检验与临床
出版日期:
2016-01-25

文章信息/Info

Title:
Evaluation of Serum Alpha 1-Acid Glycoprotein in Therapeutic Efficiency of Rheumatoid Arthritis
作者:
穆亚宏1; 王 瑞2a; 刘小玲2b
1.西北工业大学医院,西安 710072; 2.西安市第五医院 a.老干部病科; b.检验科,西安 710082
Author(s):
MU Ya-hong1; WANG Rui2a; LIU Xiao-ling2b
1.the Hospital of Northwestern Polytechnical University,Xi'an 710072,China; 2a.Department of OldCadres; 2b.Department of Medcine Laboratory,the Fifth Hospital of Xi'an,Xi'an 710082,China
关键词:
类风湿关节炎;  α1-酸性糖蛋白;  疗效评价
分类号:
R593.22; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.01.043
文献标志码:
A
摘要:
目的 探讨血清α1-酸性糖蛋白(AAG)在类风湿关节炎(RA)患者联合给药治疗前后血清中的变化,评价血清AAG检测在RA中的初步应用。方法 选择2013年3月～2014年8月在西安市第五医院门诊及住院的初诊RA患者88例,给予甲氨蝶呤、柳氮磺吡啶和羟氯喹联合给药,于第0,6个月留取患者血清,用速率散射比浊法测定患者血清中AAG及类风湿因子(RF)水平,同时测定红细胞沉降率(erythrocyte sedimentation rate,ESR),并记录RA患者的疾病活动指数28(DAS28)。结果 治疗后RA患者血中AAG(1 136.30±322.40 mg/L),RF(43.73±4.53)IU/ml,ESR(34.56±9.21 mm/h)及DAS28(3.10±1.0)均有明显下降(P<0.05或0.01),且AAG与ESR,RF及DAS28呈正相关(r=0.19,P=0.02; r=0.24,P=0.02和r=0.39,P=0.03)。结论 RA患者血清中AAG随治疗明显变化,对RA的疗效有一定评价作用。
Abstract:
Objective To investigate serum alpha 1-acid glycoprotein(AAG)in patients with rheumatoid arthritis(RA)patients with serumdrug before and after the treatment,application of evaluation of serum alpha 1-acid glycoproteindetection in RA.Methods 88 cases of newly diagnosed RA patients treated with methotrexate,hydroxychloroquine combined with pyridine and the Liu Danhuang administration,in zeroth and June.The patients were taken for determination of serum AAG and rheumatoid factor in the serum of the patients with rate nephelometry(RF)levels,and erythrocyte sedimentation rate(ESR),and record the patients with RA disease the activity index of 28(DAS28).Results After treatment,RA in the blood of patients with AAG(1 136.30±322.40 mg/L),RF(43.73±4.53 IU/ml),ESR(34.56±9.21 mm/h)and DAS28(3.10±1.0)were significantly decreased(P<0.05 or 0.01),and the AAG,ESR,RF and DAS28 were positively correlated(r=0.19,P=0.02; r=0.24,P=0.0 and r=0.39,P=0.03).Conclusion The serum RA inpatients with AAG changes obviously,had certain curative effect evaluation of RA.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:穆亚宏(1962-),男,本科,副主任医师,主要从事临床皮肤病学研究,Tel:13991812920。
更新日期/Last Update: 2016-01-20