[1]翁震,何杨.外泌体蛋白质组学分析在心血管疾病中应用的研究进展[J].现代检验医学杂志,2018,33(04):157-159.[doi:10.3969/j.issn.1671-7414.2018.04.044]
 WENG Zhen,HE Yang.Research Progress of Proteomic Analysis of Exosomes and Its Application in Cardiovascular Disease[J].Journal of Modern Laboratory Medicine,2018,33(04):157-159.[doi:10.3969/j.issn.1671-7414.2018.04.044]
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外泌体蛋白质组学分析在心血管疾病中应用的研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第33卷
期数:
2018年04期
页码:
157-159
栏目:
综述
出版日期:
2018-08-30

文章信息/Info

Title:
Research Progress of Proteomic Analysis of Exosomes and Its Application in Cardiovascular Disease
文章编号:
1671-7414(2018)04-157-03
作者:
翁震何杨
苏州大学唐仲英血液学研究中心,江苏苏州 215123
Author(s):
WENG ZhenHE Yang
Cyrus Tang Hematology Center,Soochow University,Jiangsu Suzhou215123,China
关键词:
外泌体 蛋白质组学 心血管病 应用
分类号:
R446.11; R54
DOI:
10.3969/j.issn.1671-7414.2018.04.044
文献标志码:
A
摘要:
外泌体是由各种类型细胞从晚期内质体分泌的大小为30~100 nm的细胞外囊泡结构。多项研究显示外泌体在多种人类疾病尤其是心血管疾病中发挥着重要的作用。近来的研究显示外泌体蛋白质组学分析的方法能够成功鉴定多种外泌体相关的蛋白质,并且有助于揭示其作用效应的新机制。该文将从分析评估不同蛋白质组学技术在鉴定外泌体蛋白中的应用并讨论蛋白组学分析外泌体在心血管疾病研究中的最新进展进行综述。
Abstract:
Abstract:Exosomes were 30~100 nm extracellular vesiclessecreted from late endosomes by various types of cells.Numerous studies have suggested that exosomes play significant roles in multiple human diseases,especially cardiovascular diseases.Proteomics analysis of exosomes has been successfully used to identify various exosomal proteins and helped to uncover the novel mechanisms exerted by exosomes.This review was focused on evaluating the roles ofvarious proteomic techniques in defining exosomal contents; discussing the research and clinical applications of proteomics and exosome in cardiovascular disease.

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备注/Memo

备注/Memo:
基金项目:国家自然基金项目(81700129); 苏州市科技计划(SYS201704)。 作者简介:翁 震(1982-),男,博士,助理研究员,血管生物学方向,E-mail: zhweng@suda.edu.cn。 通讯作者:何 杨,E-mail:heyang1963@163.com。
更新日期/Last Update: 2018-08-16